...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cancer: A Journal of the American Cancer Society >Effect of exercise on metabolic syndrome in black women by family history and predicted risk of breast cancer: The FIERCE FIERCE Study
【24h】

Effect of exercise on metabolic syndrome in black women by family history and predicted risk of breast cancer: The FIERCE FIERCE Study

机译：家庭历史上对黑人女性代谢综合征的影响及预测乳腺癌的风险：激烈的激烈研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background This study examined the effects of supervised and home‐based exercise interventions on changes in metabolic syndrome (MetS) according to breast cancer risk (high vs low) in black women enrolled in the Focused Intervention on Exercise to Reduce Cancer (FIERCE) trial. Methods Postmenopausal, obese, metabolically unhealthy black women, 45 to 65 years old, were randomized to supervised aerobic exercise (73 women), home‐based walking‐based exercise (69 women), or a control arm (71 women). Participants in the exercise arms underwent a 6‐month intervention with study assessments conducted at the baseline and 6 months. The primary outcome measure was MetS (fasting glucose, waist circumference, blood pressure, serum triglycerides, and high‐density lipoprotein [HDL]). The intervention effects on MetS, stratified by breast cancer risk as measured by the family history of breast cancer and model‐based projected breast cancer risk, were examined with intent‐to‐treat analyses using generalized estimating equation models. Results Among women with a family history of breast cancer, the exercise arms had lower mean MetS z scores, which suggested an improvement in the metabolic profile, than controls at 6 months (controls,?+?0.55; home‐based arm, –0.97, P ??.01; supervised arm, –0.89, P ??.01). Stratified analyses by projected breast cancer risk suggested similar but statistically nonsignificant findings, with those at high risk having more favorable changes in the MetS z score in the exercise arms versus the control arm. These changes were primarily attributable to changes in blood pressure, triglycerides, and HDL. Conclusions Short‐term aerobic activity regimens may improve the metabolic profile and thereby reduce breast cancer risk in obese, metabolically unhealthy black women at high risk for cancer. ? 2018 American Cancer Society .
机译：背景技术本研究检测了监督和家庭的运动干预措施对代谢综合征（METS）变化的影响根据乳腺癌风险（高VS低）注册的黑人癌症，注册了对锻炼的重点干预，以减少癌症（激烈）审判。方法后期后，肥胖，代谢不健康的黑人女性，45至65岁，被随机调查有氧运动（73名妇女），家庭行走的运动（69名女性），或控制臂（71名女性）。运动臂中的参与者在基线和6个月内进行了6个月的学习评估。 Mets（空腹葡萄糖，腰围，血压，血清甘油三酯和高密度脂蛋白[HDL]）的主要结果测量。用乳腺癌和基于模型的预定乳腺癌风险的家庭史上测量的乳腺癌风险分层的对MET的干预效应进行了检查，采用广义估计方程模型进行意图分析。患有乳腺癌家族史的妇女，运动臂具有较低的平均Mets Z分数，这提出了代谢概况的改善，而不是6个月（对照，？+ 0.55;家庭型手臂，-0.97 ，p？＆lt ;?。01;监督臂，-0.89，p？＆lt ;?。01）。预计乳腺癌风险的分层分析表明了类似但统计学上的显着性调查结果，具有高风险的高风险，在运动臂与控制臂中具有更有利的变化。这些变化主要是归因于血压，甘油三酯和HDL的变化。结论短期好氧活性方案可以改善代谢型材，从而降低肥胖的乳腺癌风险，即癌症的高风险。还2018年美国癌症协会。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号