首页> 外文期刊>Anesthesiology >Different propofol-remifentanil or sevoflurane-remifentanil bispectral index levels for electrocorticographic spike identification during epilepsy surgery
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Different propofol-remifentanil or sevoflurane-remifentanil bispectral index levels for electrocorticographic spike identification during epilepsy surgery

机译:癫痫手术中不同的异丙酚-瑞芬太尼或七氟醚-瑞芬太尼双光谱指数水平用于皮层电图峰值识别

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BACKGROUND:: Medical therapy, the cornerstone of managing epilepsy, still fails a substantial portion of patients. Little information is available regarding the potential impact of different bispectral index (BIS) levels on electrocorticographic spike identification for surgical epileptic foci resection. METHODS:: Twenty-two intractable epilepsy subjects were randomly allocated to the propofol-remifentanil or sevoflurane-remifentanil groups, and were further randomized to four BIS85 (BIS 71-85), BIS70 (BIS 56-70), BIS55 (BIS 41-55), and BIS40 (BIS ≤40) sequence order. RESULTS:: Two-way ANOVA revealed no differences between groups in spike frequency (P = 0.720), spike amplitude (P = 0.647), or number of spiking leads (P = 0.653). In the propofol and sevoflurane groups, decreasing BIS levels increased mean ± SD spike/min frequency (P < 0.001 and P < 0.001) at BIS85 (10 ± 12 and 10 ± 8), BIS70 (19 ± 17 and 17 ± 15), BIS55 (22 ± 17 and 18 ± 8), and BIS40 (25 ± 15 and 23 ± 17). Furthermore, in the propofol and sevoflurane groups, decreasing BIS levels increased spike microvolt amplitude (P = 0.006 and P = 0.009) at BIS85 (1,100 ± 400 and 750 ± 400), BIS70 (1,200 ± 460 and 850 ± 490), BIS55 (1,300 ± 560 and 940 ± 700), and BIS40 (1,400 ± 570 and 1,300 ± 700). Whereas, in the propofol and sevoflurane groups, there was no difference in the location or number of spiking leads (P = 0.057 and P = 0.109) at the four BIS levels. Compared with BIS85, spike frequency in the propofol and sevoflurane groups increased 100 and 170% at BIS70, 116 and 180% at BIS55, and 132 and 230% at BIS40. Compared with BIS85, spike amplitude increased 108 and 113% at BIS70, 121 and 125% at BIS55, and 128 and 170% at BIS40. CONCLUSION:: Decreasing BIS levels in the propofol and sevoflurane groups enhanced epileptogenic spike frequency and amplitude with the same location and number of spiking leads.
机译:背景:作为治疗癫痫病的基石的药物治疗仍然使大部分患者失败。关于不同的双谱指数(BIS)水平对手术癫痫灶切除术的脑电图钉识别的潜在影响,目前尚无足够的信息。方法:将22名顽固性癫痫患者随机分为丙泊酚-瑞芬太尼或七氟醚-瑞芬太尼组,然后进一步随机分为4个BIS85(BIS 71-85),BIS70(BIS 56-70),BIS55(BIS 41- 55)和BIS40(BIS≤40)序列顺序。结果:双向方差分析显示两组之间的尖峰频率(P = 0.720),尖峰幅度(P = 0.647)或尖峰引线数量(P = 0.653)没有差异。在丙泊酚和七氟醚组中,降低的BIS水平会在BIS85(10±12和10±8),BIS70(19±17和17±15)时增加平均值±SD峰值/分钟频率(P <0.001和P <0.001), BIS55(22±17和18±8)和BIS40(25±15和23±17)。此外,在异丙酚和七氟醚组中,降低的BIS水平会在BIS85(1,100±400和750±400),BIS70(1,200±460和850±490),BIS55( 1300±560和940±700)和BIS40(1400±570和1300±700)。而在异丙酚和七氟醚组中,在四个BIS水平上,加标导线的位置或数量没有差异(P = 0.057和P = 0.109)。与BIS85相比,丙泊酚和七氟醚组的峰值频率在BIS70处分别增加100%和170%,在BIS55处分别增加116%和180%,在BIS40处增加132%和230%。与BIS85相比,BIS70的峰值幅度增加了108和113%,BIS55的峰值增加了121和125%,BIS40的峰值增加了128和170%。结论:异丙酚和七氟醚组中BIS水平的降低增强了癫痫发作的尖峰频率和振幅,而加标导线的位置和数量相同。

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