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BOP1-a key player of ribosomal biogenesis

机译：BOP1-核糖体生物发生的关键球员

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摘要

Ribosomal biogenesis involves coordination of protein complexes for translation, cell growth and differentiation. An analysis of ribosomal biogenesis factor ERB1/BOP1 in evolution and cancer was carried out using comparative bioinformatics approaches focusing on protein domain identification, phylogenetic analysis, homology modelling, analyses of gene expression and interaction networks. We have identified WD40 domain as an essential co-occurring domain in all the BOP1 proteins predominantly in eukaryotes and also identified some key structural motifs in BOP1. A strong correlation of BOP1 has been observed in multiple signalling pathways, dysregulation of which leads to cancer. Using interaction networks and data mining, which are literature-derived, we have identified important interaction partners of PeBoW complex that co-express with BOP1 in signalling pathways. Analysis of BOP1 differential gene expression and interaction pathways reveals that BOP1 plays an important role in regulating p53 signalling and cellcycle networks, and provides a crosstalk with key cellular processes. Examination of cancer and tissue expression profiling points to the upregulation of BOP1 in a variety of cancers. Thus BOP1 can be considered as a potential cancer biomarker and therapeutic target.
机译：核糖体生物发生涉及对翻译，细胞生长和分化的蛋白质复合物的协调。使用对比生物信息学方法进行核糖体生物发生因子ERB1 / BOP1的分析，这些方法在蛋白质结构域鉴定，系统发育分析，同源性建模，基因表达和相互作用网络分析。我们已经将WD40结构域识别为主要在真核生物中的所有BOP1蛋白中的基本共同发生域，并在BOP1中鉴定了一些关键结构基序。在多个信号通路中观察到BOP1的强烈相关性，其失调导致癌症。使用互动网络和数据挖掘，这些网络衍生出来，我们已经确定了在信号通道中与BOP1共同表达的击球复合体的重要交互伙伴。 BOP1差异基因表达和相互作用途径的分析表明，BOP1在调节P53信号传导和细胞网上起着重要作用，并提供具有关键蜂窝过程的串扰。检查癌症和组织表达分析指向各种癌症中BOP1的上调。因此，BOP1可以被认为是潜在的癌症生物标志物和治疗靶标。

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