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首页> 外文期刊>American Journal of Physiology >Differences in the dynamic baroreflex characteristics of unmyelinated and myelinated central pathways are less evident in spontaneously hypertensive rats
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Differences in the dynamic baroreflex characteristics of unmyelinated and myelinated central pathways are less evident in spontaneously hypertensive rats

机译：在自发性高血压大鼠中，未封闭和肢体中央途径的动态肾晕特性的差异不太明显

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摘要

The aim of the study was to identify the contribution of myelinated (A-fiber) and unmyelinated (C-fiber) baroreceptor central pathways to the baroreflex control of sympathetic nerve activity (SNA) and arterial pressure (AP) in anesthetized Wistar-Kyoto (WKY; n = 8) and spontaneously hypertensive rats (SHR; n = 8). The left aortic depressor nerve (ADN) was electrically stimulated with two types of binary white noise signals designed to preferentially activate A-fibers (A-BRx protocol) or C-fibers (C-BRx protocol). In WKY, the central arc transfer function from ADN stimulation to SNA estimated by A-BRx showed strong derivative characteristics with the slope of dynamic gain between 0.1 and 1 Hz (G_(slope)) of 14.63 ± 0.89 dB/decade. In contrast, the central arc transfer function estimated by C-BRx exhibited nonderivative characteristics with G_(slope) of 0.64 ± 1.13 dB/decade. This indicates that A-fibers are important for rapid baroreflex regulation, whereas C-fibers are likely important for more sustained regulation of SNA and AP. In SHR, the central arc transfer function estimated by A-BRx showed higher G_(slope) (18.46 ± 0.75 dB/decade, P < 0.01) and that estimated by C-BRx showed higher G_(slope) (8.62 ± 0.64 dB/decade, P < 0.001) with significantly lower dynamic gain at 0.01 Hz (6.29 ± 0.48 vs. 2.80 ± 0.36%/Hz, P < 0.001) compared with WKY. In conclusion, the dynamic characteristics of the A-fiber central pathway are enhanced in the high-modulation frequency range (0.1-1 Hz) and those of the C-fiber central pathway are attenuated in the low-modulation frequency range (0.01-0.1 Hz) in SHR.
机译：该研究的目的是鉴定髓鞘（A-FILED）和未键入（C-纤维）的助长中央途径对麻醉Wistar-Kyoto（ WKY; n = 8）和自发性高血压大鼠（SHR; N = 8）。用两种类型的二进制白噪声信号电刺激左主动脉减压器神经（ADN），该二进制白噪声信号被设计为优先激活A纤维（A-BRX协议）或C-FIBERS（C-BRX协议）。在WKY中，来自ADN刺激的中央电弧传递函数对A-BRX估计的SNA估计的强大衍生特性，动态增益斜率为0.1至1 Hz（G_（斜率）），为14.63±0.89 dB /十年。相反，C-BRX估计的中央电弧传递函数表现出0.64±1.13 dB /十年的G_（斜率）的非立力特性。这表明A-纤维对于快速的Baroreflex调节很重要，而C纤维可能对于更持续调节SNA和AP可能是重要的。在SHR中，A-BRX估计的中央电弧传递函数显示得更高的G_（斜率）（18.46±0.75dB / deadade，P <0.01），并且由C-BRX估计显示较高的G_（斜率）（8.62±0.64 dB /与WKY相比，十年，P <0.001）以0.01Hz的动态增益显着降低（6.29±0.48与2.80±0.36％/ Hz，P <0.001）。总之，在高调制频率范围（0.1-1Hz）中增强了A纤维中央途径的动态特性，并且C-光纤中央途径的那些在低调制频率范围内衰减（0.01-0.1 Hz）在shr。

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