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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Merkel Cell Carcinoma Clinically Mimicking a Traumatic Suture Scar in the Nasal Vestibule: Earlier Diagnosis for Better Prognosis
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Merkel Cell Carcinoma Clinically Mimicking a Traumatic Suture Scar in the Nasal Vestibule: Earlier Diagnosis for Better Prognosis

机译：Merkel细胞癌临床上模仿鼻前庭的创伤缝合疤痕：早期的诊断以便更好的预后

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Background: Merkel cell carcinoma (MCC) is an aggressive form of skin cancer that is often found in sun-exposed regions of the skin in older or immunocompromised individuals. To date there have only been four cases reported of MCC found in the nasal vestibule. Case Report: We document an unusual case of MCC in the nasal vestibule of a 66-year-old female which was clinically believed to be an inflammatory reaction to a previous suture scar. The patient also had a history of dermatitis treated with UV light. The lesion was less than 5 mm in the greatest dimension and biopsied. There was small blue cell infiltrate in the dermis and the tumor cells were positive for synaptophysin, chromogranin and cytokeratin 20. They were negative for S100 proteins, melan A, human melanoma black 45 (HMB45) and lymphocyte common antigen CD45. For Ki-67, staining was positive in 90% of the tumor cells and tumor protein 53 immunoreactivity showed a wild type staining pattern. The pathological diagnosis was MCC and the patient underwent Mohs surgery with no tumor recurrence or metastasis identified at 2.5 years of follow-up. Conclusion: To the best of our knowledge, cases of MCC arising in the nasal vestibule with clinical features mimicking a suture scar have not been reported. The importance of early diagnosis and treatment of MCC to improve patient prognosis are discussed.
机译：背景：Merkel细胞癌（MCC）是一种侵略性的皮肤癌形式，通常在较老的皮肤暴露的皮肤区域中发现或免疫功能性的个体。迄今为止，纳尔前庭发现的MCC只有四个案例。案例报告：我们在66岁女性的鼻前庭中记录了一个不寻常的MCC案例，该鼻前庭在临床上被认为是对先前缝合瘢痕的炎症反应。患者还有用UV光处理的皮炎病史。在最大的尺寸和活检中，病变小于5毫米。在真皮中存在小的蓝色细胞浸润，肿瘤细胞对于突触蛋白，Chormogranin和细胞角蛋白20呈阳性。它们对S100蛋白质，Melan A，人黑素瘤黑45（HMB45）和淋巴细胞常见抗原CD45是阴性的。对于KI-67，染色为90％的肿瘤细胞和肿瘤蛋白53免疫反应性显示出野生型染色模式。病理诊断为MCC，患者接受了MOHS手术，没有肿瘤复发或转移在2.5岁的后续行动。结论：据我们所知，尚未报告鼻前庭中产生的MCC病例，尚未涉及模仿缝合疤痕的临床特征。讨论了早期诊断和治疗MCC以改善患者预后的重要性。

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