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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Recent Developments Towards the Synthesis of Vitamin D Metabolites
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Recent Developments Towards the Synthesis of Vitamin D Metabolites

机译：最近对维生素D代谢物合成的发展

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摘要

Due to latest advancements in the development of LC-MS/MS based assays and their applications in clinical chemistry, low abundant vitamin D metabolites can be detected at low concentration with high specificity. Consequently, there is a growing need for their synthesis as stable isotopically labeled compounds to be used as calibration and reference standards. Most commonly, ex chiral pool synthesis, starting with vitamin D-2, and palladium(0) catalyzed coupling reactions are applied in vitamin D synthesis. By contrast, little is known so far regarding the application of cobalt complexes for this purpose. In fact, the Pausen-Khand reaction can be applied for the synthesis of a wide range of isotopically labeled vitamin D metabolites that are hardly accessible by other known methods. Applications, scope and limitations of the most recent vitamin D synthesis methods, with a particular focus on this new promising methodology using Co-complexes, are discussed.
机译：由于基于LC-MS / MS的测定和它们在临床化学中的应用的最新进展，可以以高特异性低浓度检测低丰富的维生素D代谢物。 因此，它们的合成需要越来越需要，作为稳定的同位素标记的化合物，以用作校准和参考标准。 最常见的是，从维生素D-2开始的前手性池合成，催化偶联反应催化偶联反应在维生素D合成中。 相比之下，到目前为止众所周知，关于这种目的的钴配合物的应用。 实际上，普森宫反应可以应用于合成各种同位素标记的维生素D代谢物，其几乎不能通过其他已知方法可获得。 讨论了最近维生素D合成方法的应用，范围和限制，特别关注使用共复合物的这种新的承诺方法。

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