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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Preoperative Survival Prediction in Patients With Glioblastoma by Routine Inflammatory Laboratory Parameters
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Preoperative Survival Prediction in Patients With Glioblastoma by Routine Inflammatory Laboratory Parameters

机译：常规炎症实验室参数术治疗胶质母细胞瘤患者的术前存活预测

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Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults and still carries a dismal prognosis. As several studies detected a connection between inflammation and GBM prognosis, we sought to explore possible associations between routinely investigated inflammatory parameters and GBM outcome. Patients and Methods: Patients treated for GBM at our Institution between 2004 and 2014 were included. White blood cell count (WBC), C-reactive protein (CRP) and the ratio of platelets and WBC (Plt/WBC) were evaluated preoperatively. Medical records were reviewed for clinical parameters (age, sex, preoperative clinical condition, genetic alterations). Study endpoints were overall (OS) and 1- and 2-year survival. Results: In the final cohort consisting of 565 individuals with GBM, univariate analysis showed significant associations for WBC, CRP and Plt/WBC ratio with OS. Kaplan-Meier survival plot confirmed significantly poorer OS in patients with WBC> 12/nl and with CRP >= 2.9 mg/dl. In multivariate analysis, a WBC of > 12/nl was an independent prognostic factor for all three outcome parameters and CRP >= 2.9 mg/dl for OS and 1- year survival. Conclusion: Preoperative WBC and CRP values were confirmed as independent predictors of GBM outcome. This emphasizes the need for further evaluation of the role of inflammation in the prognosis of GBM.
机译：背景：胶质母细胞瘤（GBM）是成人中最常见的恶性脑肿瘤，仍然具有令人沮丧的预后。随着若干研究发现炎症和GBM预后的联系，我们试图探讨经常调查的炎症参数和GBM结果之间的可能关联。患者及方法：在2004年至2014年间在我们的机构治疗患者的患者。术后评估白细胞计数（WBC），C反应蛋白（CRP）和血小板和WBC（PLT / WBC）的比率。临床参数（年龄，性别，术前临床状况，遗传改变）审查了病程。研究终点是总体（OS）和1-岁和2年生存率。结果：在由565个具有GBM的群体组成的最终群组中，单变量分析显示了WBC，CRP和PLT / WBC比率的显着关联。 Kaplan-Meier生存情节在WBC> 12 / NL和CRP> = 2.9mg / dL中确认了较差的OS。在多变量分析中，WBC> 12 / NL是所有三种结果参数的独立预后因子，OS和1年生存率的所有三种结果参数和CRP> = 2.9mg / DL。结论：术前WBC和CRP值被证实为GBM结果的独立预测因子。这强调需要进一步评估炎症在GBM预后的作用。

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