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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The Effect of Various Doses of Oral Vitamin D-3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study
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The Effect of Various Doses of Oral Vitamin D-3 Supplementation on Gut Microbiota in Healthy Adults: A Randomized, Double-blinded, Dose-response Study

机译：各种剂量口服维生素D-3补充对健康成人肠道微生物的影响：随机，双盲，剂量反应研究

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Background/Aim: To investigate the effects of vitamin D-3 supplementation on gut microbiota. Patients and Methods: Twenty adults with vitamin D insufficiency/deficiency [25(OH)D <30 ng/ml] were enrolled and given 600, 4,000 or 10,000 IUs/day of oral vitamin D-3. Stool samples were collected at baseline and 8 weeks for identifying gut microbiota using 16S rRNA gene amplification and sequencing. Results: Baseline serum 25(OH)D was associated with increased relative abundance of Akkermansia and decreased relative abundance of Porphyromonas (p<0.05). After the intervention, we observed a dose-dependent increase in relative abundance of Bacteroides with a significant difference between the 600 IUs and the 10,000 IUs groups (p=0.027), and Parabacteroides with a significant difference between the 600 IUs and the 4,000 IUs groups (p=0.039). Conclusion: Increased serum 25(OH)D was associated with increased beneficial bacteria and decreased pathogenic bacteria. A dose-dependent increase in bacteria associated with decreased inflammatory bowel disease activity was observed after vitamin D-3 supplementation.
机译：背景/目的：探讨维生素D-3补充对肠道微生物的影响。患者和方法：20名具有维生素D不足/缺乏的成人[25（OH）D <30 ng / mL]注册，并给予600,4,000或10,000 ius /天口服维生素D-3。在基线和8周收集粪便样品，用于使用16S rRNA基因扩增和测序识别肠道微生物。结果：基线血清25（OH）D与Akkermansia的相对丰度增加和卟啉单胞菌的相对丰度降低有关（P <0.05）。干预后，我们观察到600 IUS和10,000个IUS组（P = 0.027）之间具有显着差异的拟菌体的剂量依赖性增加（P = 0.027），以及600 IUS和4,000个IUS组之间具有显着差异的偶曲线（p = 0.039）。结论：增加血清25（OH）D与增加的有益细菌和降低的病原细菌有关。在维生素D-3补充后观察到与降低炎症肠疾病活性相关的细菌的剂量依赖性增加。

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