...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Geo-location of Oncological Diseases in the Extra-urban Areas of Naples and Creation of Territorial Biobanks: An Important Tool to Study Potential Connections Between Environmental Factors and Cancer
【24h】

Geo-location of Oncological Diseases in the Extra-urban Areas of Naples and Creation of Territorial Biobanks: An Important Tool to Study Potential Connections Between Environmental Factors and Cancer

机译：那不勒斯的肿瘤疾病的地理位置和领土生物人物的创造：研究环境因素与癌症之间潜在联系的重要工具

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many areas of the Campania region of Italy are more frequently at risk of neoplastic diseases due to environmental factors. However, the results of epidemiological studies, although numerous and detailed, do not explain tumor pathogenesis mechanisms in relation to the contribution of exposure to environmental pollutants. The Oncological Biobank of the G. Pascale Foundation (BBI) centralizes the collection and storage of biomaterials, both healthy and pathological human tissues, from urban and extra-urban areas of Naples, associating them with clinicopathological characteristics (type of tumor, histological type, grading, immunohistochemical and molecular profile, etc.). Geo-location of tumor samples is made by an IT platform in which demographic and clinical data are systematically uploaded. For the extra-urban areas of Naples, our experience of tumor sample geolocation highlighted cancer types with high impact of environmental pollutants as being lung, gastric and bladder cancer. In this mini-review, we underline that the possibility of specifically selecting tumor samples in circumscribed territories may allow targeted studies to verify potential connections between environmental factors and cancer. Moreover, the collection of biological fluids (serum, saliva, urine) from healthy individuals from specific areas may be a useful tool for the research of specific genetic polymorphisms linked to individual susceptibility.
机译：由于环境因素，意大利坎帕尼亚地区的许多地区的意大利地区更频繁地受到肿瘤疾病的风险。然而，流行病学研究的结果，虽然众多和细致，但不解释肿瘤发病机制与暴露于环境污染物的贡献。 G. Pascale基金会（BBI）的肿瘤学生物银行集中了生物材料的收集和储存，健康和病理人体组织，来自那不勒斯的城市和地区，将它们与临床病理特征（肿瘤类型，组织学型）相关联，分级，免疫组织化学和分子谱等）。肿瘤样本的地理位置由IT平台制成，其中系统地上上传了人口统计学和临床​​数据。对于那不勒斯的地区，我们的肿瘤样本地理位置经验强调了环境污染物影响的癌症类型为肺，胃和膀胱癌。在该迷你审查中，我们强调了特异性地选择肿瘤样本在外接的领土中的可能性可以允许有针对性的研究来验证环境因素和癌症之间的潜在联系。此外，来自特定区域的健康个体的生物流体（血清，唾液，尿液）的收集可能是研究与个体易感性相关的特定遗传多态性的有用工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号