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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Human Polyomaviruses Are Not Frequently Present in Cancer of the Salivary Glands
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Human Polyomaviruses Are Not Frequently Present in Cancer of the Salivary Glands

机译：人的多瘤不存在于唾液腺的癌症中

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Background/Aim. Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor subtypes was examined. Materials and Methods: Ninety-one primary tumors, including 12 subtypes and eight corresponding metastases, were analyzed for the presence of DNA of 10 different human PyV species by a bead-based multiplex assay using polymerase chain reaction and Luminex analyses. Results. Three samples, one adenocarcinoma (not otherwise specified), one adenoid cystic carcinoma, and one mucoepidermoid carcinoma were found to be positive. However, the amount of MCPyV DNA in these tumors was estimated to be less than one genome per tumor cell. Conclusion. The analysis of DNA from 10 human PyVs in a large number of malignant salivary gland cancers did not implicate any of these human PyVs as an important causative agent in any of the 12 subtypes studied.
机译：背景/目标。唾液腺的恶性肿瘤是稀有的和异质的，具有超过20个亚型，并主要通过组织病理学进行分类。他们的诊断往往是挑战性，他们的病因未知。这里，检查人聚瘤（PYV）与一种或多种唾液腺肿瘤亚型之间的可能关联。材料和方法：通过使用聚合酶链反应和Luminex分析，通过珠子的多重测定分析91个初级肿瘤，包括12个亚型和八种相应的转移，通过珠子的多重测定存在于10种不同人PyV物种的DNA。结果。发现三个样品，一种腺癌（未另行指定），一种腺样囊性癌和一种粘膜异常癌是阳性的。然而，估计这些肿瘤中的McPyV DNA的量估计每肿瘤细胞的一个基因组。结论。在大量的恶性唾液腺癌中分析来自10个人PyVs的DNA并未将任何这些人PyV含义在所研究的12个亚型中的任何一种重要的致病剂中。

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