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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer
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PROX1 Is Associated with Cancer Progression and Prognosis in Gastric Cancer

机译：Prox1与胃癌中的癌症进展和预后有关

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Background: It was recently reported that expression of prospero homeobox protein-1 (PROX1) is correlated with the prognosis of esophageal cancer and colorectal cancer. However, its correlation with gastric cancer is unclear. Materials and Methods: Our study analyzed the effect of PROX1 knockdown on the migration, invasion and proliferation of the MKN45 human gastric cancer cell line. The correlation between PROX1 expression levels and clinicopathological factors were also analyzed in tumor samples from 99 patients with gastric cancer. Results: Migration, invasion and proliferation were significantly reduced in MKN45 cells with PROX1 knockdown. PROX1 expression was detected in gastric cancer tissues at various levels. PROX1 expression levels were positively correlated with cancer stage, N factor, lymphatic vascular invasion, and vascular invasion in patients with gastric cancer. Analysis of overall and recurrence free survival indicated that high PROX1 expression was significantly correlated with poor prognosis. Conclusion: PROX1 can be an indicator of poor prognosis and a molecular target for gastric cancer treatment.
机译：背景：最近报道称Prospero Homeobox蛋白-1（Prox1）的表达与食道癌和结肠直肠癌的预后相关。然而，它与胃癌的相关性尚不清楚。材料和方法：我们的研究分析了Prox1敲低对MKN45人胃癌细胞系迁移，侵袭和增殖的影响。在胃癌99例患者的肿瘤样本中还分析了Prox1表达水平和临床病理因子之间的相关性。结果：使用Prox1敲低的MKN45细胞显着降低了迁移，侵袭和增殖。在各种水平的胃癌组织中检测到prox1表达。 Prox1表达水平与胃癌患者癌症阶段，N因子，淋巴管血管侵袭和血管侵袭呈正相关。分析总体和复发自由存活表明，高Prox1表达与预后差显着相关。结论：Prox1可以是预后差和胃癌治疗分子靶标的指标。

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