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首页> 外文期刊>Antimicrobial agents and chemotherapy. >A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles
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A Revised Species Concept for Opportunistic Mucor Species Reveals Species-Specific Antifungal Susceptibility Profiles

机译：用于机会粘膜物种的修订后的物种概念揭示了物种特异性抗真菌敏感性曲线

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Recently, the species concept of opportunistic Mucor circinelloides and its relatives has been revised, resulting in the recognition of its classical formae as independent species and the description of new species. In this study, we used isolates of all clinically relevant Mucor species and performed susceptibility testing using the EUCAST reference method to identify potential species-specific susceptibility patterns. In vitro susceptibility profiles of 101 mucoralean strains belonging to the genus Mucor (72), the closely related species Cokeromyces recurvatus (3), Rhizopus (12), Lichtheirnia (10), and Rhizornucor (4) to six antifungals (amphotericin B, natamycin, terbinafine, isavuconazole, itraconazole, and posaconazole) were determined. The most active drug for all Mucorales was amphotericin B. Antifungal susceptibility profiles of pathogenic Mucor species were specific for isavuconazole, itraconazole, and posaconazole. The species formerly united in M. circinelloides showed clear differences in their antifungal susceptibilities. Cokeromyces recurvatus, Mucor ardhlaengiktus, Mucor lusitanicus (M. circinelloides f. lusitanicus), and Mucor ramosissimus exhibited high MICs to all azoles tested. Mucor indicus presented high MICs for isavuconazole and posaconazole, and Mucor amphibiorum and Mucor irregularis showed high MICs for isavuconazole. MIC values of Mucor spp. for posaconazole, isavuconazole, and itraconazole were high compared to those for Rhizopus and the Lichtheimiaceae (Lichtheirnia and Rhizomucor). Molecular identification combined with in vitro susceptibility testing is recommended for Mucor species, especially if azoles are applied in treatment.
机译：最近，经过修订了机会粘膜环素及其亲属的物种概念，导致其古典形式作为独立物种以及新物种的描述。在这项研究中，我们使用了所有临床相关的粘膜物种的分离物，并使用EUCAST参考方法进行了易感性测试，以识别潜在的特异性敏感性模式。在体外敏感性曲线属于粘膜属（72），密切相关的物种Cokomyces Refurvatus（3），Rhizopus（12），Lichtheirnia（10）和根瘤病（4）至六种抗真菌（两性霉素B，Natamycin测定三萘芬，异戊基唑，伊唑康唑和己酰基唑。所有粘膜最活跃的药物是两性霉素B.致病性粘膜物种的抗真菌敏感性谱对异戊基唑，伊戊糖唑和己酰基唑类特异性。以前联合在M.Incinelloides的物种在抗真菌敏感性上表现出明显的差异。 Cokeromyces Refurvatus，Mucor Ardhlaengiktus，粘膜Lusitanicus（M.Circinelloides f.Lusitanicus），粘膜ramosissimus表现出对所有测试的所有氮的麦克风。粘膜抑制含量为异戊酰唑和吡酰基唑，粘膜宏观孔和粘膜Inregularis为异戊酰唑而呈现出高麦克风。 MUCOR SPP的MIC值。对于波萨沙唑，异丙唑和伊伐唑唑氏菌与根瘤菌和丽氏菌（LichTheirnia和Rhizomuc）相比高。对于粘膜物种，建议将分子鉴定与体外敏感性测试相结合，特别是如果氮孔被应用于治疗。

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