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首页> 外文期刊>Antimicrobial agents and chemotherapy. >The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs
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The Alternative Sigma Factors SigE and SigB Are Involved in Tolerance and Persistence to Antitubercular Drugs

机译：替代的Sigma因子SiGe和SigB参与耐受性和持久性对抗细胞药物

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The emergence and spread of drug-resistant Mycobacterium tuberculosis strains possibly threaten our ability to treat this disease in the future. Even though two new antitubercular drugs have recently been introduced, there is still the need to design new molecules whose mechanisms of action could reduce the length of treatment. We show that two alternative sigma factors of M. tuberculosis (SigE and SigB) have a major role in determining the level of basal resistance to several drugs and the amount of persisters surviving long-duration drug treatment. We also demonstrate that ethambutol, a bacteriostatic drug, is highly bactericidal for M. tuberculosis mutants missing either SigE or SigB. We suggest that molecules able to interfere with the activity of SigE or SigB not only could reduce M. tuberculosis virulence in vivo but also could boost the effect of other drugs by increasing the sensitivity of the organism and reducing the number of persisters able to escape killing.
机译：耐药性结核分枝杆菌菌株的出现和传播可能威胁到未来治疗这种疾病的能力。 尽管最近介绍了两种新的抗细胞药，但仍有需要设计新分子，其作用机制可以降低治疗的长度。 我们展示了两种替代的M.Tuberculosis（SiGe和SigB）的替代Σ因素在确定基础抗性水平对几种药物和持续时间的持续剂量的持续时间的持续剂量中具有重要作用。 我们还证明了抑菌药物，抑制菌药，对于缺少SiGe或SigB的结核突变体是高杀菌的。 我们认为，能够干扰SiGe或Sigb活性的分子不仅可以减少体内的结核病毒力，而且可以通过增加有机体的敏感性并减少能够逃脱杀戮的持久性的敏感性来提高其他药物的影响 。

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