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Emerging antibacterial nanomedicine for enhanced antibiotic therapy

机译：用于增强抗生素治疗的新出现的抗菌纳米医生

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摘要

Antibiotic therapy is the most powerful strategy for treating bacterial infections in clinic. However, antibiotic resistance has become one of the biggest threats to public health worldwide due to the misuse and abuse of antibiotics. What is worse, the speed of the discovery of new antibiotics is largely hysteretic compared to the growth of antibiotic resistance. The world is on the threshold of the "post-antibiotic era". Nanomaterials have shown great potential in restoring the antibacterial activity of conventional antibiotics by different mechanisms, including optimizing pharmacokinetics, improving antibiotic internalization, interfering with bacterial metabolism, enhancing biofilm penetration, changing biofilm microenvironments, and so on. The combination of nanotechnology and antibiotics would be the most promising strategy to cope with antibiotic-resistant bacteria. In this review, the mechanisms of antibiotic resistance are introduced and the recent strategies for improving the therapeutic efficacy of antibiotics to combat drug resistance using nanomaterials are summarized. The advantages and mechanisms of nanoparticlebased antibiotics are overviewed as well. Moreover, the challenges of nano-antibiotics in clinical applications have also been discussed.
机译：抗生素治疗是治疗临床细菌感染的最强大的策略。然而，由于滥用和滥用抗生素，抗生素抗性已成为全世界对公共卫生的最大威胁之一。更糟糕的是，与抗生素抗性的生长相比，新抗生素发现的速度很大程度上是滞后。世界正处于“抗生素后时代”的门槛上。纳米材料通过不同机制恢复常规抗生素抗菌活性的巨大潜力，包括优化药代动力学，改善抗生素内化，干扰细菌代谢，增强生物膜渗透，改变生物膜微环境等。纳米技术和抗生素的组合将是应对抗生素抗性细菌的最有希望的策略。在本次综述中，概述了抗生素抗性的机制，并且总结了改善抗生素治疗抗性使用纳米材料对抗耐药性的抗药性的策略。概述了纳米粒子基于抗生素的优点和机制。此外，还讨论了纳米抗生素在临床应用中的挑战。

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  • 来源
    《Biomaterials Science》 |2020年第24期|共15页
  • 作者

    Shuting Wang; Yifan Gao; Qiao Jin; Jian Ji;

  • 作者单位

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China;

    MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China;

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  • 正文语种 eng
  • 中图分类 计量学;
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