Lipid Droplet Biogenesis

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Lipid Droplet Biogenesis

机译：脂质液滴生物发生

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Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo, converting cells to emulsions with LDs constituting the dispersed oil phase in the aqueous cytoplasm. Here we review our current view of LD biogenesis. We present a model of LD formation from the ER in distinct steps and highlight the biology of proteins that govern this biophysical process. Areas of incomplete knowledge are identified, as are connections with physiology and diseases linked to alterations in LD biology.

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《Annual review of cell and developmental biology》 |2017年第2017期|共20页
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正文语种 eng
中图分类细胞生物学;
关键词
biogenesis; endoplasmic reticulum; lipid droplets; neutral lipids; seipin; sterol esters; triglycerides; triacylglycerol;

机译：生物生成;内质网;脂液滴;中性脂质;Seipin;甾醇酯;甘油三酯;三酰基甘油;

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1. Proteomics Analysis of Lipid Droplets from the Oleaginous Alga Chromochloris zofingiensis Reveals Novel Proteins for Lipid Metabolism [J] . Xiaofei Wang, Hehong Wei, Xuemei Mao, 基因组蛋白质组与生物信息学报（英文版） . 2019,第003期
2. RNF34 modulates the mitochondrial biogenesis and exercise capacity in muscle and lipid metabolism through ubiquitination of PGC-1 in Drosophila [J] . Ping Wei, Jihui Guo, Wen Xue, 生物化学与生物物理学报：英文版 . 2018,第010期
3. Degradation of lipid droplets by chimeric autophagy-tethering compounds [J] . Yuhua Fu, Ningxie Chen, Ziying Wang, 细胞研究（英文版） . 2021,第009期
4. Biogenesis and functions of lipid droplets in plants Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man [J] . Journal of Lipid Research . 2012,第2期

机译：植物脂质滴的生物发生和功能专题综述系列：脂质滴的合成与代谢：从酵母到人
5. Biogenesis and functions of lipid droplets in plants: Thematic review series: Lipid droplet synthesis and metabolism: From yeast to man [J] . ChapmanK.D., DyerJ.M., MullenR.T. Journal of Lipid Research . 2012,第2期

机译：植物脂质滴的生物发生和功能：专题综述系列：脂质滴的合成和代谢：从酵母到人
6. Seipin performs dissectible functions in promoting lipid droplet biogenesis and regulating droplet morphology [J] . Bethany R. Cartwright, Derk D. Binns, Christopher L. Hilton, Molecular biology of the cell . 2015,第4期

机译：脂蛋白在促进脂质小滴的生物发生和调节小滴的形态方面具有可分解的功能
7. Lipid bilayer on a droplet: Formation of lipid bilayers on a droplet array [C] . Tonooka T., Takeuchi S. Micro Electro Mechanical Systems (MEMS), 2012 IEEE 25th International Conference on . 2012

机译：液滴上的脂质双层：在液滴阵列上形成脂质双层
8. An ER-dependent lipid droplet formation model—A subcellular localization study of multiple proteins involved in lipid droplet biogenesis, and, Lipid droplet association of RDH10 and its functional study [D] . Jiang, Weiya 2008

机译：依赖ER的脂质滴形成模型—涉及脂质滴生物发生的多种蛋白质的亚细胞定位研究以及RDH10的脂质滴缔合及其功能研究
9. Small GTPase Rab40c Associates with Lipid Droplets and Modulates the Biogenesis of Lipid Droplets [O] . Ran Tan, Weijie Wang, Shicong Wang, -1

机译：小GTPase Rab40c与脂质液滴结合并调节脂质液滴的生物发生。
10. Small GTPase Rab40c Associates with Lipid Droplets and Modulates the Biogenesis of Lipid Droplets [O] . Tan Ran, Wang Weijie, Wang Shicong, 2013

机译：小GTPase Rab40c与脂质液滴结合并调节脂质液滴的生物发生。
11. Two New Plant-Like Pathways Link Hemoglobin Degradation to Lipid Biogenesis in Falciparum Malaria: Novel Targets for Anti-Malarial Chemotherapy [R] . Mamoun, C. B. 2005

机译：两种新的类植物途径将恶性血红蛋白降解为恶性疟疾中的脂质生物合成：抗疟疾化疗的新靶点

Lipid Droplet Biogenesis

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