Diagnosis and management of Specific Antibody Deficiency

Perez Elena E.; Ballow Mark

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Diagnosis and management of Specific Antibody Deficiency

机译：特异性抗体缺乏的诊断和管理

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Specific antibody deficiency is a primary immunodeficiency disease recognized by the International Union of Immunology Societies and defined by recurrent respiratory infections with normal immunoglobulins, but diminished antibody responses to polysaccharide antigens after vaccination with the 23 valent pneumococcal polysaccharide vaccine. Clinical immunologists struggle with diagnosis and treatment, because the definition of an adequate response to immunization remains controversial. Specific antibody deficiency is managed clinically with close follow-up and prompt treatment of infections, antibiotic prophylaxis, or immune globulin therapy. Treatment is individualized using clinical judgment and existing practice guidelines, which will likely evolve as more studies become available.

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《Immunology and allergy clinics of North America》 |2020年第3期|共13页
作者
Perez Elena E.; Ballow Mark;
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作者单位

Allergy Associates Palm Beaches 840 Us Highway 1 Suite 235 North Palm Beach FL 33408 USA;

Univ S Florida Dept Pediat Div Allergy &

Immunol All Childrens Res Inst Johns Hopkins Childrens;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Specific antibody deficiency; Antibody deficiency; Diagnosis; Immunoglobulin replacement therapy; Pneumococcal vaccines; PCV13; PPSV23; Primary immunodeficiency;

机译：特异性抗体缺乏;抗体缺乏;诊断;免疫球蛋白替代疗法;肺炎球菌疫苗;PCV13;PPSV23;初级免疫缺陷;

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专利

1. INFLUENCE OF IRON DEFICIENCY ON SERUM IgG SUBCLASS AND PNEUMOCOCCAL POLYSACCHARIDES SPECIFIC IgG SUBCLASS ANTIBODIES [J] . 冯学斌, 杨锡强, 沈锦中华医学杂志：英文版 . 1994,第011期
2. Development of a Specific CHIKV-E2 Monoclonal Antibody for Chikungunya Diagnosis [J] . Jaemoo Kim, Jihyun Yang, Young Bong Kim, 中国病毒学：英文版 . 2019,第005期
3. Treponema pallidum-specific antibody expression for the diagnosis of different stages of syphilis [J] . SUN Ran, LAI Di-hui, REN Rong-xin, 中华医学杂志（英文版） . 2013,第002期
4. Corrigendum: Specific Antibody Deficiency: Controversies in Diagnosis and Management [J] . Elena Perez, Francisco A. Bonilla, Jordan S. Orange, Frontiers in Immunology . 2018,第1期

机译：更正：特定抗体缺陷：诊断和管理中的争议
5. Specific Antibody Deficiency: Controversies in Diagnosis and Management [J] . Perez, Elena Frontiers in Immunology . 2017,第12期

机译：特定抗体缺乏症：诊断和管理中的争议
6. Specific Antibody Deficiency: Controversies in Diagnosis and Management [J] . Elena Perez, Francisco A. Bonilla, Jordan S. Orange, Frontiers in Immunology . 2017,第12期

机译：特定抗体缺乏症：诊断和管理中的争议
7. Circulating CD21low B cells are Decreased in Children with Recurrent Respiratory Infections with or without Specific Antibody Deficiency (SAD). [C] . Leiva L.E., Harvey T., Lefevre S., European Society Immunodeficiencies., Meeting. . 2013

机译：循环CD21Low B细胞在具有或不具有特异性抗体缺乏（SAD）的呼吸呼吸道感染的儿童中减少。
8. Harnessing Antibodies for Treating Pancreatic Cancer: AR9.6 a MUC16 Specific Monoclonal Antibody [D] . Aguilar, Eric Nunez. 2021

机译：用于治疗胰腺癌的抗体：AR9.6 A型MUC16特异性单克隆抗体
9. Consensus on diagnosis and management of primary antibody deficiencies. Consensus Panel for the Diagnosis and Management of Primary Antibody Deficiencies. [O] . H. M. Chapel 1994

机译：关于一抗缺乏症的诊断和处理的共识。诊断和管理原发性抗体缺乏症共识小组。
10. Specific Antibody Deficiency: Controversies in Diagnosis and Management [O] . Elena Perez, Francisco A. Bonilla, Jordan S. Orange, 2017

机译：特异性抗体缺乏：诊断和管理中的争议
11. Monoclonal antibody (SZ-51) specific for activated platelets is useful in the diagnosis of thrombosis. Final report for the period December 1990 - April 1994 [R] . Ruan, C. 1994

机译：对活化血小板特异的单克隆抗体（sZ-51）可用于血栓形成的诊断。 1990年12月至1994年4月期间的最后报告

Diagnosis and management of Specific Antibody Deficiency

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