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首页> 外文期刊>Annals of allergy, asthma, and immunology >Factors that predict the success of cyclosporine treatment for chronic urticaria.
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Factors that predict the success of cyclosporine treatment for chronic urticaria.

机译:预测环孢霉素治疗慢性荨麻疹成功的因素。

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摘要

BACKGROUND: Chronic urticaria (CU) is a frequent, difficult clinical problem. When first-line therapy fails, patients are often treated with alternative therapies that either have a poor side effect profile or little evidence to support effectiveness. OBJECTIVE: To describe our low-dose cyclosporine-treated CU population and factors predicting a positive outcome. METHODS: A retrospective chart review was conducted of adult CU patients treated with cyclosporine. Elements of the history, physical examination, diagnostic testing, efficacy, and side effects were extracted for statistical analysis. RESULTS: Chronic urticaria was defined as having urticaria more than 3 days per week for 6 consecutive weeks. Sixty-eight adults with CU who fulfilled the intake criteria and completed a course of cyclosporine were identified. After taking cyclosporine at an average dose of 1.8 +/- 1.1 mg/kg, 53 (78%) patients attained complete remission defined as /=10 predict a successful response.
机译:背景:慢性荨麻疹(CU)是一个常见的,困难的临床问题。当一线治疗失败时,通常会用替代疗法来治疗患者,这些疗法要么不良反应,要么没有证据支持有效性。目的:描述低剂量环孢素治疗的CU人群和预测阳性结果的因素。方法:回顾性图表回顾了接受环孢素治疗的成人CU患者。提取病史,体格检查,诊断测试,功效和副作用的元素进行统计分析。结果:慢性荨麻疹的定义是连续6周每周荨麻疹超过3天。确定了符合摄入标准并完成了环孢素疗程的68名成人CU。 53(78%)名患者平均以1.8 +/- 1.1 mg / kg的剂量服用环孢菌素后,达到完全缓解,即每月荨麻疹 / = 10预示成功。

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