GluD2-and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells

Takeo Yukari H.; Shuster S. Andrew; Jiang Linnie; Hu Miley C.; Luginbuhl David J.; Rulicke Thomas; Contreras Ximena; Hippenmeyer Simon; Wagner Mark J.; Ganguli Surya; Luo Liqun

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GluD2-and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells

机译：Glud2和CBLN1介导的竞争性相互作用塑造了小脑紫癜细胞的树突仲裁液

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The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, but this hypothesis has not been causally tested in vivo in the mammalian brain. The presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex. Here we show that sparse but not global knockout of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular layer and overelaboration in the superficial molecular layer. Developmental, overexpression, structure-function, and genetic epistasis analyses indicate that these dendrite morphogenesis defects result from a deficit in Cbln1/GluD2-dependent competitive interactions. A generative model of dendrite growth based on competitive synaptogenesis largely recapitulates GluD2 sparse and global knockout phenotypes. Our results support the synaptotrophic hypothesis at initial stages of dendrite development, suggest a second mode in which cumulative synapse formation inhibits further dendrite growth, and highlight the importance of competition in dendrite morphogenesis.

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《Neuron》 |2021年第4期|共25页
作者
Takeo Yukari H.; Shuster S. Andrew; Jiang Linnie; Hu Miley C.; Luginbuhl David J.; Rulicke Thomas; Contreras Ximena; Hippenmeyer Simon; Wagner Mark J.; Ganguli Surya; Luo Liqun;
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Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

Stanford Univ Neurosci Program Stanford CA 94305 USA;

Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

Univ Vet Med Vienna Inst Lab Anim Sci Vienna Austria;

IST Austria Campus 1 A-3400 Klosterneuburg Austria;

IST Austria Campus 1 A-3400 Klosterneuburg Austria;

Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

Stanford Univ Dept Appl Phys Stanford CA 94305 USA;

Stanford Univ Howard Hughes Med Inst Dept Biol Stanford CA 94305 USA;

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正文语种 eng
中图分类神经病学;
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3. Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome [J] . Liping Peng, Mingxian Li, Shao Wang, 中国神经再生研究（英文版） . 2012,第008期
4. Coexistence of dopamine-beta-hydroxylase and activated protein-2 alpha in rat cerebellar Purkinje cells [J] . Kejian Wang, Wei Li, Shanquan Sun, 中国神经再生研究（英文版） . 2009,第006期
5. Chronic pharmacological blockade of the Na+/Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures [J] . Sherkhane Pradeep, Kapfhammer Josef P. The European Journal of Neuroscience . 2017,第5a6期

机译：Na + / Ca2 +交换剂的慢性药理学阻断调节小鼠小脑切片培养物中Purkinje细胞树突树突的生长和发育
6. Mitochondrial fission protein Drp1 regulates mitochondrial transport and dendritic arborization in cerebellar Purkinje cells [J] . Fukumitsu Kansai, Hatsukano Tetsu, Yoshimura Azumi, Molecular and cellular neurosciences . 2016,第Null期

机译：线粒体裂变蛋白Drp1调节小脑浦肯野细胞中的线粒体转运和树突状乔化
7. Post-hatch development of dendritic arborization in cerebellar Purkinje neurons of quail chicks: a morphometric study. [J] . Mori M, Matsushima T Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2002,第1期

机译：鹌鹑小脑浦肯野神经元树突状乔化的孵化后发展：形态学研究。
8. STRUCTURAL REAPPRAISAL OF DENDRITIC TREE OF CEREBELLAR PURKINJE CELL FOR NOVEL FUNCTIONAL MODELING OF ELEMENTARY SENSORIMOTOR ADAPTIVE PROCESSES [C] . Laszlo Simon, Sandor Garab, Annamaria Noszek European Symposium on Life Sciences in Space . 2005

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9. Differential time course of loss of guinea pig cerebellar Purkinje cells and hippocampal CA1 pyramidal cells produced by chronic prenatal ethanol exposure and the role of apoptosis. [D] . McGoey, Tara Nadine. 2001

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10. Cav2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring Cell Survival and Cerebellar Biochemical Compartmentalization [O] . Taisuke Miyazaki, Miwako Yamasaki, Kouichi Hashimoto, 2012

机译：小脑浦肯野细胞中的Cav2.1调节竞争性兴奋性突触接线细胞存活和小脑生化分隔。
11. Ca(v)2.1 in Cerebellar Purkinje Cells Regulates Competitive Excitatory Synaptic Wiring, Cell Survival, and Cerebellar Biochemical Compartmentalization [O] . Miyazaki, Taisuke, Yamasaki, Miwako, Hashimoto, Kouichi, 2012

机译：小脑浦肯野细胞中的Ca（v）2.1调节竞争性兴奋性突触接线，细胞存活和小脑生化隔室。
12. Cerebellar Purkinje Cell Activity Related to the Classically Conditioned Nictitating Membrane Response [R] . Berthier, N. E., Moore, J. W. 1986

机译：小脑浦肯野细胞活动与经典条件的瞬膜反应有关

GluD2-and Cbln1-mediated competitive interactions shape the dendritic arbors of cerebellar Purkinje cells

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