• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of Botany >The role of multifunctional M1 metallopeptidases in cell cycle progression
【24h】

The role of multifunctional M1 metallopeptidases in cell cycle progression

机译：多功能M1金属肽酶在细胞周期进程中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Metallopeptidases of the M1 family are found in all phyla (except viruses) and are important in the cell cycle and normal growth and development. M1s often have spatiotemporal expression patterns which allow for strict regulation of activity. Mutations in the genes encoding M1s result in disease and are often lethal. This family of zinc metallopeptidases all share the catalytic region containing a signature amino acid exopeptidase (GXMXN) and a zinc binding (HEXXH[18X]E) motif. In addition, M1 aminopeptidases often also contain additional membrane association and/or protein interaction motifs. These protein interaction domains may function independently of M1 enzymatic activity and can contribute to multifunctionality of the proteins.Scope A brief review of M1 metalloproteases in plants and animals and their roles in the cell cycle is presented. In animals, human puromycin-sensitive aminopeptidase (PSA) acts during mitosis and perhaps meiosis, while the insect homologue puromycin-sensitive aminopeptidase (PAM-1) is required for meiotic and mitotic exit; the remaining human M1 family members appear to play a direct or indirect role in mitosis/cell proliferation. In plants, meiotic prophase aminopeptidase 1 (MPA1) is essential for the first steps in meiosis, and aminopeptidase M1 (APM1) appears to be important in mitosis and cell division.Conclusions M1 metalloprotease activity in the cell cycle is conserved across phyla. The activities of the multifunctional M1s, processing small peptides and peptide hormones and contributing to protein trafficking and signal transduction processes, either directly or indirectly impact on the cell cycle. Identification of peptide substrates and interacting protein partners is required to understand M1 function in fertility and normal growth and development in plants.
机译：背景M1家族的金属肽酶存在于所有门（病毒除外）中，并且在细胞周期和正常生长发育中很重要。 M1通常具有时空表达模式，可以对活动进行严格调节。编码M1的基因突变会导致疾病，并且通常是致命的。该锌金属肽酶家族均共享包含特征性氨基酸外肽酶（GXMXN）和锌结合（HEXXH [18X] E）基序的催化区域。此外，M1氨基肽酶通常还包含其他膜结合和/或蛋白质相互作用基序。这些蛋白质相互作用域可能独立于M1酶活性起作用，并且可以促进蛋白质的多功能性。作用范围简要概述了动植物中M1金属蛋白酶及其在细胞周期中的作用。在动物中，人嘌呤霉素敏感性氨基肽酶（PSA）在有丝分裂甚至减数分裂期间起作用，而昆虫同源嘌呤霉素敏感性氨基肽酶（PAM-1）是减数分裂和有丝分裂退出所必需的。其余的人类M1家族成员似乎在有丝分裂/细胞增殖中直接或间接起作用。在植物中，减数分裂前期氨基肽酶1（MPA1）对于减数分裂的第一步是必不可少的，而氨基肽酶M1（APM1）在有丝分裂和细胞分裂中似乎很重要。结论M1金属蛋白酶在细胞周期中的活性在整个门系中都是保守的。多功能M1的活动直接或间接影响细胞周期，加工小肽和肽激素并促进蛋白质运输和信号转导过程。鉴定肽底物和相互作用的蛋白质伴侣是了解M1在育性和植物正常生长发育中的功能所必需的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号