...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dermatitis: contact, atopic, occupational, drug : official journal of the American Contact Dermatitis Society, North American Contact Dermatitis Group >Patch Testing of Mercaptobenzothiazole and Mercapto Mix: The North American Contact Dermatitis Group Experience, 1994-2016
【24h】

Patch Testing of Mercaptobenzothiazole and Mercapto Mix: The North American Contact Dermatitis Group Experience, 1994-2016

机译：巯基噻唑和巯基混合的补丁测试：北美联系皮炎群体体验，1994-2016

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives Mercapto compounds are a category of rubber accelerators that may cause allergic contact dermatitis. This study characterizes patch test reactions to mercaptobenzothiazole (MBT) and mercapto mix (MM) in a large North American population. Methods The 1994-2016 North American Contact Dermatitis Group screening series data were analyzed. Patients with allergic reactions to either MBT or MM (mercapto+) were included. The following characteristics were analyzed: strength of reaction, clinical and occupational relevance, coreactivity with other rubber accelerators, and sources of exposure. Results A total of 49,795 patients were tested to mercapto compounds from 1994 to 2016; 633 (1.3%) had positive reactions to MBT and/or MM. The frequency to both MBT and MM significantly decreased over time (P < 0.0001). Mercapto+ patients were significantly more likely to be male, have occupationally related skin disease, and report involvement of the hands and/or feet (P < 0.0001). They were significantly less likely to have face, scalp/ears/neck, or trunk involvement (P <= 0.0001). There was significant coreactivity with carba mix (23.4%) and thiuram mix (32.5%). Mercaptobenzothiazole and MM reactions were frequently clinically (81.7% and 83.5%, respectively) and occupationally relevant (29.8% and 33.4%, respectively). Gloves were the most common source (31.3% and 30.9%, respectively). Conclusions Patch test positivity to mercapto compounds significantly decreased from 1994 to 2016 but remains clinically and occupationally relevant.
机译：目的巯基化合物是一类可能引起过敏性接触性皮炎的橡胶促进剂。本研究描述了大量北美人群对巯基苯并噻唑（MBT）和巯基混合物（MM）的斑贴试验反应。方法对1994-2016年北美接触性皮炎组筛查系列数据进行分析。包括对MBT或MM（巯基+）有过敏反应的患者。分析了以下特征：反应强度、临床和职业相关性、与其他橡胶促进剂的核心活性以及暴露来源。结果从1994年到2016年，共有49795名患者接受了巯基化合物检测；633例（1.3%）对MBT和/或MM呈阳性反应。MBT和MM的频率随时间显著降低（P<0.0001）。巯基+患者明显更可能是男性，患有职业相关皮肤病，并报告手和/或脚受累（P<0.0001）。他们面部、头皮/耳朵/颈部或躯干受累的可能性显著降低。carba mix（23.4%）和thiuram mix（32.5%）具有显著的核心活性。巯基苯并噻唑和MM反应经常出现在临床（分别为81.7%和83.5%）和职业相关（分别为29.8%和33.4%）。手套是最常见的来源（分别为31.3%和30.9%）。结论从1994年到2016年，巯基化合物的斑贴试验阳性率显著降低，但仍与临床和职业相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号