...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Medical Virology >Role of gamma delta T cells in exacerbated airway inflammation during reinfection of neonatally primed mice in adulthood
【24h】

Role of gamma delta T cells in exacerbated airway inflammation during reinfection of neonatally primed mice in adulthood

机译：Gamma Delta T细胞在Adulthood在新生儿初步小鼠中加剧期间的气道炎症中的作用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Age at primary infection with respiratory syncytial virus (RSV) is a crucial factor in determining the outcome of reinfection. However, how neonatal RSV infection affects the immune system and renders the host more susceptible to reinfection in later life is poorly understood. In the present study, by using BALB/c mice that were first infected with RSV as neonates, the role of gamma delta T cells in the development of airway inflammation during reinfection in adulthood was investigated. We found that neonatal RSV infection resulted in an aggravated infiltration of mononuclear cells in bronchoalveolar lavage (BAL) fluids, in parallel with a significant increase in the levels of type 2 cytokines in lungs on day 4 after reinfection. Since the numbers of total gamma delta T cells as well as activated gamma delta T cells, particularly IL-4-, IL-5-, and IL-13-producing gamma delta T cells, were enhanced markedly in the lungs of neonatally primed mice, we speculate that gamma delta T cells might participate in the augmented airway inflammation seen during reinfection. Indeed, depletion of gamma delta T cells attenuated the severity of lung histopathology during reinfection. Meanwhile, treatment of neonatal mice with anti-TCR mAb diminished not only the numbers of neutrophils, eosinophils, and lymphocytes, but also the levels of IL-4, IL-5, and IL-13 in the lungs after reinfection in adulthood, suggesting that gamma delta T cells, particularly Th2-type gamma delta T cells might play a critical role in exacerbating the pulmonary tissue pathology during reinfection of adult mice that were first infected as neonates.
机译：初次感染呼吸道合胞病毒（RSV）的年龄是决定再次感染结果的关键因素。然而，新生儿呼吸道合胞病毒感染如何影响免疫系统，并使宿主在以后的生活中更容易再次感染，人们对此知之甚少。在本研究中，通过将首次感染RSV的BALB/c小鼠作为新生儿，研究了成年期再感染期间γδT细胞在气道炎症发展中的作用。我们发现，新生儿呼吸道合胞病毒感染导致支气管肺泡灌洗液（BAL）中的单核细胞浸润加剧，同时在再次感染后第4天，肺部2型细胞因子水平显著升高。由于在新生预处理小鼠的肺中，总γδT细胞和激活的γδT细胞，尤其是产生IL-4、IL-5和IL-13的γδT细胞的数量显著增加，我们推测γδT细胞可能参与了再感染期间出现的气道炎症增加。事实上，在再感染期间，γδT细胞的缺失减轻了肺组织病理学的严重程度。同时，用抗TCR单克隆抗体治疗新生小鼠，不仅减少了中性粒细胞、嗜酸性粒细胞和淋巴细胞的数量，还降低了成年期再感染后肺中IL-4、IL-5和IL-13的水平，这表明γδT细胞，尤其是Th2型γ-δT细胞可能在成年小鼠再次感染期间加重肺组织病理学中发挥关键作用，而成年小鼠在新生儿时首次感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号