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首页> 外文期刊>Journal of neuroendocrinology >Metabolic functions of prolactin: Physiological and pathological aspects
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Metabolic functions of prolactin: Physiological and pathological aspects

机译：催乳素的代谢功能：生理和病理方面

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摘要

Prolactin is named after its vital role of promoting milk production during lactation, although it has been implicated in multiple functions within the body, including metabolism and energy homeostasis. Prolactin has been hypothesised to play a key role in driving many of the adaptations of the maternal body to allow the mother to meet the physiological demands of both pregnancy and lactation, including the high energetic demands of the growing foetus followed by milk production to support the offspring after birth. Prolactin receptors are found in many tissues involved in metabolism and food intake, such as the pancreas, liver, hypothalamus, small intestine and adipose tissue. We review the literature examining the effects of prolactin in these various tissues and how they relate to changes in function in physiological states of high prolactin, such as pregnancy and lactation, and in pathological states of hyperprolactinaemia in the adult. In many cases, whether prolactin promotes healthy metabolism or leads to dysregulation of metabolic functions is highly dependent on the situation. Overall, although prolactin may not play a major role in regulating metabolism and body weight outside of pregnancy and lactation, it definitely has the ability to contribute to metabolic function.
机译：催乳素因其在哺乳期促进产奶的重要作用而得名，尽管它与身体内的多种功能有关，包括新陈代谢和能量平衡。据推测，催乳素在推动母亲身体的许多适应过程中起着关键作用，以使母亲能够满足怀孕和哺乳的生理需求，包括生长中胎儿的高能量需求，然后生产牛奶以支持出生后的后代。催乳素受体存在于参与新陈代谢和食物摄入的许多组织中，如胰腺、肝脏、下丘脑、小肠和脂肪组织。我们回顾了研究催乳素在这些不同组织中的作用的文献，以及它们与高催乳素生理状态（如妊娠和哺乳期）和成人高催乳素血症病理状态下的功能变化的关系。在许多情况下，催乳素是促进健康的新陈代谢还是导致代谢功能失调在很大程度上取决于情况。总的来说，尽管催乳素在孕期和哺乳期之外可能不会在调节新陈代谢和体重方面发挥主要作用，但它肯定有能力促进新陈代谢功能。

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