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首页> 外文期刊>Annals of tropical medicine and parasitology >Efficacy of artesunate in the treatment of urinary schistosomiasis, in an endemic community in Nigeria.
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Efficacy of artesunate in the treatment of urinary schistosomiasis, in an endemic community in Nigeria.

机译：青蒿琥酯在尼日利亚一个流行社区中治疗尿血吸虫病的功效。

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The efficacy and tolerability of oral artesunate for the treatment of urinary schistosomiasis was assessed among schoolchildren aged 5-18 years in Adim community, Nigeria. Overall, 500 children, randomly selected from those attending the Presbyterian primary school, were each invited to provide two consecutive urine samples. Using standard parasitological procedures, Schistosoma haematobium ova were found in the samples from 145 (29.0%) of the subjects. Most (87) of the infected subjects were then treated orally with artesunate, using two doses, each of 6 mg/kg, given 2 weeks apart. When the treated children were re-examined 4 weeks after the second dose of artesunate, 61 (70.1%) appeared egg-negative and were therefore considered cured. Post-treatment, the geometric mean egg count (GMEC) for the treated subjects who were not cured was significantly lower than the pre-treatment GMEC for all the treated subjects, with log10[(eggs/10 ml urine) + 1] values of 0.9 v. 1.75 (t = 4.45; P < 0.05). The cure 'rate' for the subjects aged > or = 10 years was slightly higher than that among the younger subjects. It was lowest for the heavier subjects (70% for those weighing 41-50 kg) and highest (79%) for the subjects who weighed 31-40 kg. The artesunate was well tolerated. This observation of a therapeutic effect of artesunate against S. haematobium in Nigeria confirms recent observations from Senegal. In the Adim community at least, it would be more cost-effective to treat urinary schistosomiasis with artesunate than with praziquantel. The wide-spread use of artesunate against schistosomiasis has to be considered carefully, however, if it is not to compromise the efficacy of the drug as an antimalarial, by increasing the risk of resistance developing in local Plasmodium.
机译：在尼日利亚阿迪姆社区的5-18岁小学生中评估了口服青蒿琥酯治疗尿血吸虫病的疗效和耐受性。总体而言，从长老会小学就读的儿童中随机选择了500名儿童，每人连续提供两次尿液样本。使用标准的寄生虫学程序，在145名（29.0％）受试者的样品中发现了血吸虫血卵。然后，大多数（87）受感染的受试者接受青蒿琥酯口服治疗，使用两次剂量，每次6 mg / kg，间隔2周。在第二剂青蒿琥酯给药后4周对接受治疗的儿童进行了重新检查，发现61例（70.1％）鸡蛋阴性，因此被认为已治愈。治疗后，未治愈的治疗对象的几何平均卵数（GMEC）明显低于所有治疗对象的治疗前GMEC，log10 [（鸡蛋/ 10 ml尿液）+ 1]的值为0.9诉1.75（t = 4.45; P <0.05）。年龄大于或等于10岁的受试者的治愈“率”略高于年轻受试者。体重较重的受试者最低（41-50公斤体重的受试者为70％），体重31-40公斤的受试者最高（79％）。青蒿琥酯耐受性良好。青蒿琥酯对尼日利亚血红霉病的治疗作用的这一观察结果证实了来自塞内加尔的最新观察结果。至少在Adim社区，用青蒿琥酯治疗尿血吸虫病比使用吡喹酮治疗更具成本效益。但是，如果不能通过增加局部疟原虫产生耐药性的风险来损害青蒿琥酯对血吸虫病的广泛使用，以防止损害该药物作为抗疟药的功效，则必须谨慎考虑。

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