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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis
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Clinical Characteristics of Stroke with COVID-19: A Systematic Review and Meta-Analysis

机译：Covid-19中风的临床特征：系统评价和荟萃分析

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Background: The coronavirus disease 2019 (COVID-19) potentially increases the risk of thromboembolism and stroke. Numerous case reports and retrospective cohort studies have been published with mixed characteristics of COVID-19 patients with stroke regarding age, comorbidities, treatment, and outcome. We aimed to depict the frequency and clinical characteristics of COVID-19 patients with stroke. Methods: PubMed and EMBASE were searched on June 10, 2020, to investigate COVID-19 and stroke through retrospective cross-sectional studies, case series/reports according to PRISMA guidelines. Study-specific estimates were combined using one-group meta-analysis in a random-effects model. Results: 10 retrospective cohort studies and 16 case series/reports were identified including 183 patients with COVID-19 and stroke. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% ([95% confidential interval (CI)]: [0.6-1.6], I-2 = 62.9%). Mean age was 66.6 ([58.4-74.9], I-2 = 95.1%), 65.6% was male (61/93 patients). Mean days from symptom onset of COVID-19 to stroke was 8.0 ([4.1-11.9], p < 0.001, I-2 = 93.1%). D-dimer was 3.3 mu g/mL ([1.7-4.9], I-2 = 86.3%), and cryptogenic stroke was most common as etiology at 50.7% ([31.0-70.4] I-2 = 64.1%, 39/71 patients). Case fatality rate was 44.2% ([27.9-60.5], I-2 = 66.7%, 40/100 patients). Conclusions: This systematic review assessed the frequency and clinical characteristics of stroke in COVID-19 patients. The frequency of detected stroke in hospitalized COVID-19 patients was 1.1% and associated with older age and stroke risk factors. Frequent cryptogenic stroke and elevated d-dimer level support increased risk of thromboembolism in COVID-19 associated with high mortality. Further study is needed to elucidate the pathophysiology and prognosis of stroke in COVID-19 to achieve most effective care for this population.
机译：背景：2019年冠状病毒病（COVID-19）可能增加血栓栓塞和中风的风险。2019冠状病毒疾病患者的年龄、并发症、治疗和预后的混合特征已发表。我们旨在描述2019冠状病毒疾病患者的频率和临床特征。方法：2019冠状病毒疾病和EMPASE，2020年6月10日通过PISMA指南回顾性横断面研究、病例系列/报告进行检索。在随机效应模型中，使用一组荟萃分析结合研究特定的估计。结果：共回顾2019冠状病毒疾病10例，16例病例报告，其中183例COVID-19和脑卒中。COVID2019冠状病毒疾病患者的脑卒中检出率为1.1%（95%保密区间（CI）：[0.6～1.6]，I-2＝62.9%）。平均年龄为66.6岁（[58.4-74.9]，I-2=95.1%），65.6%为男性（61/93患者）。COVID2019冠状病毒疾病发作的平均天数为8（[4.1-119]，P＜0.001，I-2＝93.1%）。D-二聚体为3.3μg/mL（[1.7-4.9]，I-2=86.3%），隐源性卒中最常见的病因为50.7%（[31.0-70.4]I-2=64.1%，39/71例患者）。病死率为44.2%（[27.9-60.5]，I-2=66.7%，40/100名患者）。结论：系统评价2019冠状病毒疾病患者的卒中频率和临床特征。COVID2019冠状病毒疾病患者的卒中检出率为1.1%，与年龄和卒中危险因素有关。2019冠状病毒疾病和高D-二聚体水平的升高支持了COVID-19血栓栓塞的风险，死亡率高。需要进一步的研究来阐明COVID-19脑卒中的病理生理和预后，以实现对该人群的最有效的治疗。

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