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首页> 外文期刊>Journal of women’s health >The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review
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The Effect of Transdermal Estrogen Patch Use on Cardiovascular Outcomes: A Systematic Review

机译：透皮雌激素贴剂对心血管结果的影响：系统评价

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Background: Vasomotor symptoms are the most commonly reported menopausal symptoms. Hormone therapy has been widely used to relieve postmenopausal symptoms. With studies suggesting an increased risk of cardiovascular events and breast cancer with oral hormone therapy use, there has been reluctance to use it. The transdermal estrogen patch provides relief from menopausal symptoms. However, there are limited data on mortality and cardiovascular outcomes, while on the transdermal estrogen patch. Methods: An extensive search in Cochrane and PubMed databases was conducted up to February 2016. The selection criteria included healthy, peri-, and postmenopausal women between the ages of 50 and 79 and should have received transdermal estrogen therapy. The relationship between estrogen patch use and cardiovascular outcomes was analyzed. Six articles met the criteria and were included. Results: We found some evidence suggestive of protective cardiovascular effects with transdermal estrogen therapy with a decrease in the risk of stroke and no increase in the risk of coronary heart disease, death, or myocardial infarction. Discussion: This is one of the first systematic reviews addressing the association of transdermal estrogen patch use on cardiovascular outcomes. We found some evidence suggestive of a possible protective cardiovascular effect with transdermal estrogen therapy. Further randomized controlled studies are needed with a longer duration of follow-up, to study the cardiovascular effects of transdermal estrogen patches.
机译：背景：血管舒缩症状是最常见的绝经期症状。激素疗法已被广泛用于缓解绝经后症状。研究表明，口服激素治疗会增加心血管事件和乳腺癌的风险，因此人们一直不愿使用激素。雌激素透皮贴片可以缓解更年期症状。然而，关于死亡率和心血管结局的数据有限，而关于雌激素透皮贴片的数据有限。方法：截至2016年2月，在Cochrane和PubMed数据库中进行了广泛搜索。选择标准包括50至79岁的健康、围绝经期和绝经后女性，且应接受雌激素透皮疗法。分析雌激素贴片使用与心血管结局之间的关系。有六篇文章符合标准并被纳入。结果：我们发现一些证据表明，经皮雌激素治疗具有心血管保护作用，可降低中风风险，但不增加冠心病、死亡或心肌梗死的风险。讨论：这是第一篇系统性综述，阐述了经皮雌激素贴片的使用与心血管结局的关系。我们发现一些证据表明，雌激素透皮疗法可能具有心血管保护作用。需要进一步的随机对照研究和更长的随访时间，以研究经皮雌激素贴片的心血管效应。

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