• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annual Review of Analytical Chemistry >Analytical and Biological Methods for Probing the Blood-Brain Barrier
【24h】

Analytical and Biological Methods for Probing the Blood-Brain Barrier

机译：探测血脑屏障的分析和生物学方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The blood-brain barrier (BBB) is an important interface between the peripheral and central nervous systems. It protects the brain against the infiltration of harmful substances and regulates the permeation of beneficial endogenous substances from the blood into the extracellular fluid of the brain. It can also present a major obstacle in the development of drugs that are targeted for the central nervous system. Several methods have been developed to investigate the transport and metabolism of drugs, peptides, and endogenous compounds at the BBB. In vivo methods include intravenous injection, brain perfusion, positron emission tomography, and microdialysis sampling. Researchers have also developed in vitro cell-culture models that can be employed to investigate transport and metabolism at the BBB without the complication of systemic involvement. All these methods require sensitive and selective analytical methods to monitor the transport and metabolism of the compounds of interest at the BBB.
机译：血脑屏障（BBB）是周围和中枢神经系统之间的重要接口。它可以保护大脑免受有害物质的渗透，并调节有益内源性物质从血液向大脑细胞外液的渗透。在开发针对中枢神经系统的药物方面，它也可能构成主要障碍。已经开发出几种方法来研究药物，肽和内源性化合物在血脑屏障中的转运和代谢。体内方法包括静脉注射，脑灌注，正电子发射断层扫描和微透析采样。研究人员还开发了体外细胞培养模型，该模型可用于研究BBB的转运和代谢，而不会引起全身性并发症。所有这些方法都需要灵敏和选择性的分析方法，以监测目标化合物在血脑屏障上的转运和代谢。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号