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首页> 外文期刊>Annals of epidemiology >Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative.
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Correlates of serum alpha- and gamma-tocopherol in the Women's Health Initiative.

机译：妇女健康倡议中血清α-和γ-生育酚的相关性。

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PURPOSE: There is increasing evidence that vitamin E (primarily alpha- and gamma-tocopherol) may reduce the risk of cardiovascular disease and some cancers, therefore it is important to understand factors that influence blood levels.METHODS: The correlates of serum alpha- and gamma-tocopherol were investigated among participants in the Women's Health Initiative (WHI), a 40-site disease prevention trial. Subjects were 1047 postmenopausal women aged 50-79 years, who provided fasting blood specimens and detailed information on diet, supplement use, and other factors at entry to the study (1994-96).RESULTS: Total serum cholesterol and triglycerides were highly correlated with serum alpha- and gamma-tocopherol concentrations and were controlled for in all analyses along with age, ethnicity and body mass index (BMI). Alpha and gamma-tocopherol were strongly negatively correlated (partial r = -0.69). The strongest predictor of serum tocopherols was average daily intake of vitamin E from supplements (partial r = 0.60 for alpha, r = -0.54 for gamma). Other factors associated with increased alpha- and/or decreased gamma-tocopherol concentrations were serum retinol and carotenoids, supplemental vitamin C, alpha-tocopherol intake from food, dietary fiber, and Hispanic ethnicity. Factors associated with lower alpha- and/or higher gamma-tocopherol concentrations included gamma-tocopherol intake from food, total fat intake, and BMI. Age, income, hormone use, and geographic location were "spuriously" associated with serum tocopherol levels through their association with supplement use, i.e., there was no such association among the subset of women not taking supplements.CONCLUSIONS: Vitamin E intake from supplements and BMI are the major independent predictors of serum tocopherol levels in women, whereas dietary factors only play a small role.
机译：目的：越来越多的证据表明维生素E（主要是α-和γ-生育酚）可以降低患心血管疾病和某些癌症的风险，因此了解影响血液水平的因素非常重要。方法：血清α-和在40个站点​​的疾病预防试验“妇女健康倡议（WHI）”的参与者中对γ-生育酚进行了调查。受试者为1047名50-79岁的绝经后妇女，他们在研究开始时提供了空腹血液样本以及饮食，补充剂使用和其他因素的详细信息（1994-96年）。结果：血清总胆固醇和甘油三酸酯与血清α-和γ-生育酚的浓度以及所有年龄，种族和体重指数（BMI）均受控制。 α和γ-生育酚高度负相关（部分r = -0.69）。血清生育酚的最强预测因子是补充剂中维生素E的平均每日摄入量（α部分为r = 0.60，γ部分为r = -0.54）。与α-和/或γ-生育酚浓度升高相关的其他因素是血清视黄醇和类胡萝卜素，补充维生素C，食物中的α-生育酚摄入量，膳食纤维和西班牙裔种族。与较低的α-和/或较高的γ-生育酚浓度相关的因素包括食物中的γ-生育酚摄入量，总脂肪摄入量和BMI。年龄，收入，激素的使用和地理位置通过与补充剂的使用“虚假地”与血清中的生育酚水平相关联，即，在未服用补充剂的女性子集中没有这种关联。 BMI是女性血清生育酚水平的主要独立预测因子，而饮食因素仅起很小的作用。

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