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首页> 外文期刊>Annals of epidemiology >Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients.
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Risk of leukemia among survivors of testicular cancer: a population-based study of 42,722 patients.

机译：睾丸癌幸存者患白血病的风险：一项基于人群的研究，涉及42722名患者。

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PURPOSE: The aim of this study is to quantify excess absolute risk (EAR) and excess relative risk (ERR) of secondary leukemia among a large population-based group of testicular cancer survivors. METHODS: We identified 42,722 1-year survivors of testicular cancer within 14 population-based cancer registries in Europe and North America (1943-2002). Poisson regression analysis was used to model EAR (per 100,000 person-years [PY]) and ERR of secondary leukemia. Cumulative risks were calculated using a competing risk model. RESULTS: Secondary leukemia developed in 89 patients (EAR = 10.8 per 100,000 PY, 95% confidence interval [CI] = 7.6-14.6; ERR = 1.6, 95%CI = 1.0-2.2). Statistically significantly elevated risks were observed for acute myeloid leukemia (AML) (EAR = 7.2, 95%CI = 4.7-10.2) and acute lymphoblastic leukemia (EAR = 1.3, 95%CI = 0.4-2.8). In multivariate analyses, AML risk was higher among patients whose initial management included chemotherapy compared to those receiving radiotherapy alone (p = 0.1). Excess cumulative leukemia risk was approximately 0.23% by 30 years after testicular cancer diagnosis. CONCLUSIONS: Although ERR of leukemia following testicular cancer is large, EAR and cumulative risk, which are better gauges of the population burden, are small.
机译：目的：本研究的目的是量化基于人群的睾丸癌幸存者群体中继发性白血病的绝对绝对危险度（EAR）和相对危险度相对过量（ERR）。方法：我们在欧洲和北美（1943-2002年）的14个基于人群的癌症登记册中确定了42,722名1年睾丸癌幸存者。 Poisson回归分析用于模拟EAR（每100,000人年[PY]）和继发性白血病的ERR。使用竞争风险模型计算累积风险。结果：89例患者发生了继发性白血病（EAR =每100,000 PY 10.8，95％置信区间[CI] = 7.6-14.6; ERR = 1.6，95％CI = 1.0-2.2）。急性髓性白血病（AML）（EAR = 7.2，95％CI = 4.7-10.2）和急性淋巴细胞白血病（EAR = 1.3，95％CI = 0.4-2.8）的统计学风险显着升高。在多变量分析中，与仅接受放疗的患者相比，最初接受化疗的患者中发生AML的风险更高（p = 0.1）。睾丸癌诊断后30年，累积白血病过多的风险约为0.23％。结论：尽管睾丸癌后白血病的ERR很大，但能更好地衡量人口负担的EAR和累积风险却很小。

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