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首页> 外文期刊>Annals of epidemiology >Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) levels and thyroid function in Air Force veterans of the Vietnam War.
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Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) levels and thyroid function in Air Force veterans of the Vietnam War.

机译：越战空军退伍军人的血清2,3,7,8-四氯二苯并-对-二恶英（TCDD）水平和甲状腺功能。

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PURPOSE: We assessed potential health effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentration in serum on thyroid function in US Air Force veterans involved in Operation Ranch Hand, the unit responsible for the aerial spraying of herbicides, including TCDD-contaminated Agent Orange, during the Vietnam War from 1962 to 1971. Other Air Force veterans who were not involved with spraying herbicides were included as Comparisons. METHODS: We analyzed thyroxine (total T4), thyroid stimulating hormone (TSH), triiodothyronin percent uptake (T3% uptake), the free thyroxine index (FTI), and thyroid diseases against serum TCDD levels. Data was available for 1,009 Ranch Hand and 1,429 Comparison veterans compliant to any of five examinations in 1982, 1985, 1987, 1992, and 1997. Each veteran was assigned to one of four exposure categories based on serum TCDD levels, named Comparison, Ranch Hand Background, Ranch Hand Low Elevated, and Ranch Hand High Elevated. RESULTS: Cross-sectional analyses found statistically significantly increased TSH means at the 1985 and 1987 examinations in the High category and a significant increasing trend across the three Ranch Hand TCDD categories in 1982, 1985, 1987 and 1992. A repeated-measures analysis found significantly increased TSH means in the High TCDD category. We found no significant relation between the occurrence of thyroid disease and TCDD category. CONCLUSIONS: These findings suggest that TCDD affects thyroid hormone metabolism and function in Ranch Hand veterans. Further follow-up will be necessary to understand the relation, if any, between thyroid disease and TCDD levels.
机译：目的：我们评估了血清中2,3,7,8-四氯二苯并-对-二恶英（TCDD）浓度对参与牧场手行动的美国空军退伍军人甲状腺功能的潜在健康影响，该部队负责空中喷洒除草剂包括在1962年至1971年的越南战争期间受TCDD污染的特工Orange。其他未使用喷洒除草剂的空军退伍军人也包括在内。方法：我们根据血清TCDD水平分析了甲状腺素（总T4），甲状腺刺激激素（TSH），三碘甲状腺素摄取百分比（T3％摄取），游离甲状腺素指数（FTI）和甲状腺疾病。已有1982年，1985年，1987年，1992年和1997年符合五项检查中的任何一项的1,009名牧场手和1,429名比较退伍军人的数据。根据血清TCDD水平，每位退伍军人都被划分为四个暴露类别之一，称为比较，牧场手背景，高低放牧场手和高高放牧场手。结果：横断面分析发现，在1985年和1987年的高级检查中，TSH均值在统计学上显着增加，而在1982、1985、1987和1992年的三个牧场手TCDD类别中，TSH均呈显着增加趋势。 TSH的增加意味着高TCDD类别。我们发现甲状腺疾病的发生与TCDD类别之间无显着关系。结论：这些发现表明TCDD影响牧场手退伍军人的甲状腺激素代谢和功能。有必要进一步随访以了解甲状腺疾病与TCDD水平之间的关系。

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