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Maternal psychiatric disorders and risk of preterm birth

机译：产妇精神病和早产风险

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Purpose: To study the effect of maternal psychiatric disorders (depression, anxiety disorder, bipolar disease, schizophrenia, unspecified psychiatric disorder, and comorbid conditions) and odds of preterm birth. Methods: The Consortium on Safe Labor (2002-2008), an observational cohort with 12 centers from across the United States included 223,394 singleton pregnancies with clinical data obtained from electronic medical records and maternal diagnoses of psychiatric disorders from maternal discharge summaries. Length of gestation was based on the best clinical estimate and categorized as birth less than 39, less than 37, less than 34, and less than 28 weeks' gestation. The adjusted odds ratios (ORs) with 95% confidence intervals of birth were estimated by logistic regression with generalized estimating equations. Results: Any maternal psychiatric disorder was associated with odds of birth less than 39 weeks' gestation (odds ratio [OR] = 1.32, 95% confidence interval = 1.28-1.37), less than 37 weeks' gestation (OR = 1.45, 1.38-1.52), less than 34 weeks' gestation (OR = 1.47, 1.35-1.59), and less than 28 weeks' gestation (OR = 1.57, 1.36-1.82). Specifically, odds of birth less than 37 weeks' gestation were associated with maternal depression (OR = 131, 1.23-1.40), anxiety disorder (OR = 1.68, 1.41-2.01), depression with anxiety disorder (OR = 2.31, 1.93-2.78), bipolar disease (OR = 1.54, 1.22-1.94), bipolar disease with depression and/or anxiety disorder (OR = 1.70, 130-2.22), and unspecified psychiatric disorder (OR = 1.52, 1.41-1.64). Conclusions: Maternal psychiatric disorders, especially comorbid psychiatric conditions, were associated with increased likelihood of preterm birth. Published by Elsevier Inc.
机译：目的：研究产妇精神病（抑郁症，焦虑症，躁郁症，精神分裂症，未指明的精神病和合并症）的影响以及早产几率。方法：安全劳动联合会（2002-2008年）是一个观察性队列，有来自美国12个中心的观察性队列，其中包括223,394例单胎妊娠，其临床数据来自电子病历，并根据母亲出院总结对精神疾病进行了母亲诊断。妊娠时长是根据最佳临床估计得出的，分为出生少于39周，少于37岁，少于34周和少于28周。通过逻辑回归和广义估计方程估算出生时置信区间为95％的调整后的优势比（OR）。结果：任何孕产妇精神疾病都与小于39周妊娠的出生几率相关（赔率[OR] = 1.32，95％置信区间= 1.28-1.37），小于37周妊娠（OR = 1.45，1.38- 1.52），小于34周的妊娠（OR = 1.47、1.35-1.59）和小于28周的妊娠（OR = 1.57，1.36-1.82）。具体而言，胎龄少于37周的几率与母亲抑郁症（OR = 131，1.23-1.40），焦虑症（OR = 1.68，1.41-2.01），抑郁症伴焦虑症（OR = 2.31，1.93-2.78）相关。 ），躁郁症（OR = 1.54，1.22-1.94），患有抑郁症和/或焦虑症的躁郁症（OR = 1.70，130-2.22）和未指明的精神病（OR = 1.52，1.41-1.64）。结论：产妇精神病，特别是合并精神病，与早产的可能性增加有关。由Elsevier Inc.发布

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