• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Annals of epidemiology >Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis
【24h】

Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis

机译：使用确认性因子分析确定脂肪代谢因子作为代谢综合征的特征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: Confirmatory factor analysis (CFA) was used to test the hypothesis whether adipocytokines are associated with the risk factor cluster that characterizes the metabolic syndrome (MetS). Methods: Data from 134 nondiabetic subjects were analyzed using CFA. Insulin sensitivity (SI) was quantified using intravenous glucose tolerance tests, visceral fat area by computed tomography and fasting high-density lipoprotein, triglycerides, monocyte chemoattractant protein-1 (MCP-1), serum amyloid A (SAA), tumor necrosis factor (TNF)-α, adiponectin, resistin, leptin, interleukin (IL)-6, C-reactive protein (CRP), and plasminogen activator inhibitor (PAI)-1 were measured. Results: The basic model representing the MetS included six indicators comprising obesity, SI, lipids, and hypertension, and demonstrated excellent goodness of fit. Using multivariate analysis, MCP-1, SAA, and TNF-α were not independently associated with any of the MetS variables. Adiponectin, resistin, leptin, CRP, and IL-6 were associated with at least one of the risk factors, but when added to the basic model decreased all goodness-of-fit parameters. PAI-1 was associated with all cardiometabolic factors and improved goodness-of-fit compared with the basic model. Conclusions: Addition of PAI-1 increased the CFA model goodness of fit compared with the basic model, suggesting that this protein may represent an added feature of the MetS.
机译：目的：使用验证性因子分析（CFA）来检验脂肪细胞因子是否与表征代谢综合征（MetS）的危险因子簇相关的假设。方法：使用CFA分析来自134名非糖尿病受试者的数据。使用静脉葡萄糖耐量试验，计算机断层扫描和禁食高密度脂蛋白，甘油三酸酯，单核细胞趋化蛋白-1（MCP-1），血清淀粉样蛋白A（SAA），肿瘤坏死因子（测量了TNF）-α，脂联素，抵抗素，瘦素，白介素（IL）-6，C反应蛋白（CRP）和纤溶酶原激活物抑制剂（PAI）-1。结果：代表MetS的基本模型包括肥胖，SI，脂质和高血压六项指标，并显示出极好的拟合度。使用多变量分析，MCP-1，SAA和TNF-α与MetS变量均无关。脂联素，抵抗素，瘦素，CRP和IL-6与至少一种危险因素有关，但是当添加到基本模型中时，所有拟合优度参数都会降低。与基本模型相比，PAI-1与所有心脏代谢因子相关，并且拟合优度提高。结论：与基本模型相比，添加PAI-1可提高CFA模型的拟合优度，表明该蛋白可能代表MetS的附加功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号