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首页> 外文期刊>Annals of epidemiology >Hospitalized prenatal and childhood infections and obesity in Danish male conscripts
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Hospitalized prenatal and childhood infections and obesity in Danish male conscripts

机译：丹麦男性应征者的住院产前和儿童期感染和肥胖

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Purpose: We examined the relation between early life infections and adult obesity. Methods: A cohort of Danish males who underwent mandatory army fitness examinations was studied. Hospitalizations for childhood infections and their mothers' hospitalization for infection during pregnancy were identified via the Danish National Registry of Patients. The outcome was obesity (body mass index ≥ 30 kg/m2) at conscription. We calculated prevalence odds ratios (OR) and 95% confidence intervals (CI) associating the obesity with whether the conscript had a hospitalization for infection up to age 5, and separately, whether the conscript's mother was hospitalized for an infection prenatally. Results: Of the 17,456 men, 13% had a childhood infection (8.2% of whom were obese, compared with 7.4% without childhood infection); 1.2% of conscripts were exposed to a prenatal infection (10% of whom were obese, compared with 7.4% without prenatal infection). For childhood infection, the adjusted OR was 1.21 (95% CI, 1.01-1.44); stratified analyses suggested the association may be greater among conscripts born preterm (adjusted OR, 2.08; 95% CI, 1.06-4.09), whereas among the conscripts who were full term, the adjusted OR was 1.15 (95% CI, 0.96-1.38). For prenatal infection, the adjusted OR was 1.34 (95% CI, 0.82-2.19). Conclusions: We found a small association between both prenatal and childhood infections and prevalent obesity in early adulthood, although the results may be partly explained by unmeasured confounders.
机译：目的：我们研究了早期感染与成人肥胖之间的关系。方法：研究一组接受强制性军队体格检查的丹麦男性。通过丹麦国家患者登记处确定了儿童期感染的住院治疗以及母亲在怀孕期间感染的住院治疗。结果是肥胖（体重指数≥30 kg / m2）。我们计算了患病率，肥胖率与应征入伍者是否已住院治疗直至5岁相关的患病率比（OR）和95％置信区间（CI），并分别计算了应征入伍者的母亲是否在产前接受了感染。结果：在17456名男性中，有13％患有儿童期感染（其中8.2％为肥胖，而没有儿童期感染为7.4％）; 1.2％的应征入伍者暴露于产前感染（其中10％的人肥胖，而没有产前感染的人为7.4％）。对于儿童期感染，调整后的OR为1.21（95％CI，1.01-1.44）;分层分析显示，早产应征者的关联性可能更大（校正后OR为2.08; 95％CI为1.06-4.09），而足月应征者应校正OR为1.15（95％CI为0.96-1.38）。 。对于产前感染，校正后的OR为1.34（95％CI，0.82-2.19）。结论：尽管结果可能部分由无法衡量的混杂因素解释，但我们发现产前和儿童期感染与成年早期的普遍肥胖之间存在很小的关联。

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