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首页> 外文期刊>Annals of epidemiology >Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: The Kyushu Okinawa Maternal and Child Health Study
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Maternal fat intake during pregnancy and wheeze and eczema in Japanese infants: The Kyushu Okinawa Maternal and Child Health Study

机译：日本婴儿怀孕期间的母体脂肪摄入以及喘鸣和湿疹：九州冲绳母婴健康研究

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Purpose: This cohort study examined the relationship between maternal intake of individual fatty acids, meat, and fish during pregnancy and the risk of wheeze and eczema in children aged 23-29 months because epidemiologic evidence on this topic is inconclusive. Methods: Subjects were 1354 Japanese mother-child pairs. Data on maternal intake during pregnancy were assessed with a validated diet history questionnaire. Data on symptoms of wheeze and eczema were based on criteria of the International Study of Asthma and Allergies in Childhood. Results: Significant inverse exposure-response relationships were observed between maternal intake of eicosapentaenoic acid (EPA) and EPA plus docosahexaenoic acid (DHA) during pregnancy and infantile wheeze although the adjusted odds ratios between extreme quartiles fell just short of the significance level. No such inverse relationships were detected for infantile eczema. Maternal intake of total fat, saturated fatty acids, monounsaturated fatty acids, total n-3 polyunsaturated fatty acids (PUFA), α-linolenic acid, DHA, total n-6 PUFA, linoleic acid, arachidonic acid, cholesterol, fish, and meat and the ratio of n-3 to n-6 PUFA consumption were not significantly related to infantile wheeze or eczema. Conclusions: Higher maternal intake of EPA and EPA plus DHA during pregnancy may reduce the risk of infantile wheeze.
机译：目的：这项队列研究研究了孕妇在怀孕期间摄入个别脂肪酸，肉和鱼与23-29个月大的儿童发生喘息和湿疹的风险之间的关系，因为关于该主题的流行病学证据尚无定论。方法：受试者为1354对日本母子对。怀孕期间孕妇的摄入量数据已通过有效的饮食史问卷进行了评估。喘息和湿疹症状的数据基于国际儿童哮喘和过敏研究的标准。结果：在孕妇和婴儿喘息期间，孕妇摄入二十碳五烯酸（EPA）和EPA加二十二碳六烯酸（DHA）之间观察到显着的逆暴露-反应关系，尽管极端四分位数之间的校正比值比仅低于显着性水平。婴儿湿疹未发现这种反比关系。孕产妇摄入的总脂肪，饱和脂肪酸，单不饱和脂肪酸，总n-3多不饱和脂肪酸（PUFA），α-亚麻酸，DHA，总n-6 PUFA，亚油酸，花生四烯酸，胆固醇，鱼和肉并且n-3与n-6 PUFA的摄入量比例与婴儿气喘或湿疹无明显关系。结论：孕妇在怀孕期间较高的EPA和EPA加DHA摄入量可以降低婴儿喘息的风险。

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