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首页> 外文期刊>Annals of epidemiology >No evidence of decreased risk of colorectal adenomas with white meat, poultry, and fish intake: A meta-analysis of observational studies
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No evidence of decreased risk of colorectal adenomas with white meat, poultry, and fish intake: A meta-analysis of observational studies

机译：没有证据表明白肉，家禽和鱼摄入会降低结直肠腺瘤的风险：一项观察性研究的荟萃分析

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Purpose: Observational studies on the association between white meat (including fish and poultry) intake and the risk of colorectal adenoma (CRA), the precursor of colorectal cancer, have reported mixed results. To provide a quantitative assessment of this association, we summarized the evidence from observational studies. Methods: Relevant studies published on or before April 30, 2012 were identified from MEDLINE and EMBASE. Summary effect size estimates with 95% confidence intervals (CIs) were calculated with a random-effects model. Between-study heterogeneity was assessed using the Cochran Q and I2 statistics. Results: A total of 23 publications from 21 independent studies (16 case-control and 5 cohort studies) were included in this meta-analysis. Based on high versus low analysis, the summary effect size estimate of CRA was 0.96 (95% CI, 0.84-1.09) for white meat intake, 0.98 (95% CI, 0.80-1.19) for fish intake, and 0.98 (95% CI, 0.80-1.18) for poultry intake. Subgroup analyses revealed that the null associations of CRA with intake of white meat (fish/poultry) were independent of geographic locations, study design, type of food frequency questionnaire, number of cases, and adjustments for confounders, such as body mass index, use of nonsteroidal anti-inflammatory drugs, dietary energy intake, smoking, and physical activity. Conclusions: Intake of white meat (fish/poultry) is not associated with the risk of CRA.
机译：目的：关于白肉（包括鱼类和家禽）摄入量与大肠癌前体大肠腺瘤（CRA）风险之间关系的观察性研究报道了好坏参半。为了提供这种关联的定量评估，我们总结了观察研究的证据。方法：2012年4月30日或之前发表的相关研究资料来自MEDLINE和EMBASE。使用随机效应模型计算具有95％置信区间（CI）的汇总效应量估计值。使用Cochran Q和I2统计量评估研究之间的异质性。结果：这项荟萃分析包括来自21项独立研究的23篇出版物（16例对照研究和5项队列研究）。根据高与低的分析，白肉摄入量的CRA的总体影响大小估计值为0.96（95％CI，0.84-1.09），鱼肉摄入量的0.98（95％CI，0.80-1.19）和0.98（95％CI） ，0.80-1.18）。亚组分析显示，CRA与白肉（鱼类/家禽）摄入的无效关联与地理位置，研究设计，食物频率问卷的类型，病例数以及对混杂因素的调整（例如体重指数，使用）无关非甾体类抗炎药，饮食能量摄入，吸烟和体育锻炼。结论：摄入白肉（鱼类/家禽）与患CRA的风险无关。

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