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首页> 外文期刊>Annals of epidemiology >Investigation of the relationship between smoking and appendicitis in Australian twins.
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Investigation of the relationship between smoking and appendicitis in Australian twins.

机译：澳大利亚双胞胎吸烟与阑尾炎关系的调查。

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PURPOSE: Appendicitis is an inflammation of the appendix, the etiology of which is still poorly understood. Previous studies have shown an increased risk for cigarette smokers but no accounts for the timing of exposure to smoking relative to appendectomy were made. METHODS: Based on questionnaire data, both cohort and co-twin case-control analyses were conducted to assess the effect of active cigarette smoking on appendectomy in 3808 Australian twin pairs. Smoking status was defined as a time-dependent covariate to account for differences in timing of smoking initiation and onset of appendicitis. RESULTS: The questionnaire had a 65% pairwise response rate. After controlling for sex, age, and year of birth, appendectomy risk in current smokers was statistically significantly increased by 65% relative to never-smokers. This was largely unchanged by the duration or intensity of smoking and was not affected by socioeconomic status or father's occupation. The effect was stronger in females. Among former smokers, increased time since quitting significantly reduced the odds ratio of appendectomy by 15% for every year since quitting. CONCLUSION: After adjustment for age and other confounders, there was an increase in risk of appendectomy among current smokers relative to never-smokers, particularly in females. This study adds to the body of knowledge on the effects of tobacco smoking on the gastrointestinal tract.
机译：目的：阑尾炎是阑尾的一种炎症，其病因仍知之甚少。先前的研究表明，吸烟者的吸烟风险增加，但没有说明吸烟相对于阑尾切除术的暴露时间。方法：基于问卷调查数据，进行了队列和双胞胎病例对照分析，以评估主动吸烟对3808对澳大利亚双胞胎阑尾切除术的影响。吸烟状态定义为时间依赖性协变量，以解释吸烟开始时间和阑尾炎发作时间的差异。结果：问卷的成对应答率为65％。在控制了性别，年龄和出生年份之后，当前吸烟者的阑尾切除术风险与不吸烟者相比，统计学上显着增加了65％。吸烟的持续时间或强度在很大程度上没有变化，也不受社会经济地位或父亲职业的影响。对女性的作用更强。在以前的吸烟者中，自戒烟以来增加的时间显着减少了自戒烟以来每年阑尾切除术的几率降低15％。结论：在调整了年龄和其他混杂因素之后，相对于从未吸烟者，当前吸烟者的阑尾切除术风险增加，尤其是女性。这项研究增加了关于吸烟对胃肠道影响的知识体系。

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