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首页> 外文期刊>Annals of epidemiology >Sex steroids and age-related macular degeneration in older French women: the POLA study.
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Sex steroids and age-related macular degeneration in older French women: the POLA study.

机译：法国老年女性中的性类固醇与年龄相关的黄斑变性：POLA研究。

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PURPOSE: Postmenopausal women are reported to be at higher risk of eye diseases than men. The purpose of our study is to determine the relationships between endocrine status, specially plasma sex hormones levels, and the severity of age-related macular degeneration (AMD) in a large community-based sample of older French women. METHODS: The POLA (Pathologies Oculaires Liees a l'Age) Study is a population-based study on age-related eye diseases and their risk factors. The study enrolled 2584 residents of Southern France, among whom 1451 women aged 60 years or older were recruited between June 1995 and July 1997. A standardized international classification and grading system for AMD was used. Circulating sex hormones levels were measured from fasting blood samples. RESULTS: No association of hormone replacement therapy (HRT), hysterectomy, or oophorectomy was found with soft drusen, pigmentary abnormalities, or late AMD. After multivariate adjustment, higher plasma levels of dehydroepiandrosterone sulfate(DHEAS) were associated with a higher prevalence of soft drusen (OR = 1.21; 95% CI = 1.01-1.44). CONCLUSION: These results may indicate no beneficial effect of HRT on AMD. The positive association of DHEAS with AMD requires further investigation.
机译：目的：据报道，绝经后女性比男性更容易患眼病。我们研究的目的是确定大量以社区为基础的法国老年妇女的内分泌状态，尤其是血浆性激素水平与年龄相关性黄斑变性（AMD）严重程度之间的关系。方法：POLA（病理学眼科医师）研究是一项与年龄有关的眼疾及其危险因素的人群研究。该研究招募了2584名法国南部居民，其中1995年6月至1997年7月招募了1451名60岁或以上的女性。AMD使用了标准化的国际分类和分级系统。从空腹血样中测量循环性激素水平。结果：未发现激素替代疗法（HRT），子宫切除术或卵巢切除术与软性玻璃疣，色素异常或晚期AMD有关。经过多变量调整后，较高的血浆硫酸脱氢表雄酮（DHEAS）水平与较高的软性玻璃疣患病率相关（OR = 1.21; 95％CI = 1.01-1.44）。结论：这些结果可能表明HRT对AMD无有益作用。 DHEAS与AMD的正相关性需要进一步研究。

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