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首页> 外文期刊>Annals of epidemiology >Estimated incidence of hepatitis A virus infection in Catalonia.
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Estimated incidence of hepatitis A virus infection in Catalonia.

机译：加泰罗尼亚甲型肝炎病毒感染的估计发生率。

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PURPOSE: Hepatitis A normally is underreported by statutory disease reporting systems. The objective of this study is to estimate the incidence of hepatitis A virus (HAV) infection from prevalence surveys of infection carried out in representative samples of the population in 1989, 1996, and 2002 and the reported disease incidence during 1991 to 2003 in Catalonia. METHODS: The real incidence of the infection was estimated from the reported incidence adjusted by the prevalence of susceptible individuals and the probability of presenting clinical manifestations. The bootstrap resampling technique was used to calculate 95% confidence intervals (CIs) of reported, clinical, and all infection cases. RESULTS: The infection rate estimated by the bootstrap method was 31.1/100,000 person-years (bootstrap studentized 95% CI, 19.4-56.0), and the rate of clinical hepatitis was 20.0/100,000 person-years (95% CI, 11.8-39.9), rates that were 6.3 and 4.1 times greater than the reported rate during the same period, respectively. CONCLUSIONS: In children younger than 5 years, the estimated infection rate was 13.8 times greater than the reported rate. Combined use of reported cases and results of seroprevalence surveys suggest that underreporting of HAV infection is substantial in Catalonia, especially in children younger than 5 years.
机译：目的：法定疾病报告系统通常不会报告甲型肝炎。这项研究的目的是根据1989、1996和2002年在该人群的代表性样本中进行的感染流行率调查以及在1991年至2003年期间在加泰罗尼亚报道的疾病发病率，来估计甲型肝炎病毒（HAV）感染的发生率。方法：根据报告的发病率估算感染的实际发生率，该发病率根据易感人群的患病率和表现出临床表现的可能性进行调整。自举重采样技术用于计算已报告，临床和所有感染病例的95％置信区间（CI）。结果：自举法估计的感染率为31.1 / 100,000人年（引导自学的95％CI，19.4-56.0），临床肝炎的发生率为20.0 / 100,000人年（95％CI，11.8-39.9）。 ）的比率分别是同期报告的比率的6.3和4.1倍。结论：在5岁以下的儿童中，估计的感染率是所报告的感染率的13.8倍。结合使用已报告病例和血清阳性率调查结果表明，在加泰罗尼亚，尤其是在5岁以下的儿童中，HAV感染的报告不足。

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