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首页> 外文期刊>Annals of epidemiology >Random-effects models in investigating the effect of vitamin A in childhood diarrhea.
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Random-effects models in investigating the effect of vitamin A in childhood diarrhea.

机译：调查维生素A在儿童腹泻中的作用的随机效应模型。

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PURPOSE: By adopting more appropriate and powerful statistical methods that fully exploit longitudinal structure, we re-analyze and extend previously published results from a large community trial to investigate the effect of vitamin A supplementation on the prevalence and severity of diarrhea in young children. METHODS: Generalized linear mixed models were used to allow for repeated measures in a reanalysis of a double-blind, randomized, placebo-controlled community trial conducted in a cohort of children in northeastern Brazil during 1 year. The response variable was weekly number of days with diarrhea for each child, and Markov Chain Monte Carlo methods were used to estimate model parameters. RESULTS AND CONCLUSIONS: Random effects suitably accounted for the underlying heterogeneity between and within children, and our longitudinal analysis shows a significant beneficial effect of vitamin A supplementation that was inconclusive in previously reported simple summary analyses of these data. Risk for diarrhea infection was estimated to be 1.57 times greater for a child administered a placebo as opposed to vitamin A (95% credible interval, 1.17-2.12). Additionally, we identified previously unreported temporal effects in these data, showing a decreasing daily probability of diarrhea for both groups during the trial and treatment-time interaction.
机译：目的：通过采用更充分利用纵向结构的更合适，更强大的统计方法，我们重新分析和扩展先前在大型社区试验中发表的结果，以研究补充维生素A对幼儿腹泻患病率和严重程度的影响。方法：使用广义线性混合模型在重复分析双盲，随机，安慰剂对照的社区试验的过程中使用了重复测量方法，该试验在巴西东北部的一组儿童中进行，为期1年。反应变量是每个孩子腹泻的每周天数，并使用马尔可夫链蒙特卡洛方法估计模型参数。结果与结论：随机效应适当地解释了儿童之间和内部的潜在异质性，并且我们的纵向分析显示补充维生素A的显着有益作用在先前报道的这些数据的简单汇总分析中尚无定论。服用安慰剂的儿童腹泻感染的风险估计比维生素A高1.57倍（95％可信区间，1.17-2.12）。此外，我们在这些数据中确定了以前未报告的时间影响，表明两组在试验和治疗时相互作用期间每天腹泻的可能性正在降低。

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