Synthesis and evaluation of l-5-(2-((18)F)fluoroethoxy)tryptophan as a new PET tracer.

Li R; Wu SC; Wang SC; Fu Z; Dang Y; Huo L

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Synthesis and evaluation of l-5-(2-((18)F)fluoroethoxy)tryptophan as a new PET tracer.

机译：新型PET示踪剂1-5（2-（（（18）F）氟乙氧基）色氨酸的合成与评价

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A convenient remote controlled synthesis of a new tryptophan analog, l-5-(2-[(18)F] fluoroethoxy)-tryptophan (5-(18)FEHTP) was described. The radiochemical yield within 65min was about 12-16% without decay correction, the radiochemical purity was over 98%, and 5-(18)FEHTP dissolved in saline was stable over 6h at room temperature. The biodistribution of 5-(18)FEHTP in mice and the high uptake of 5-(18)FEHTP in tumor demonstrated that it is very likely a new PET tracer for tumor imaging.

机译：描述了新型色氨酸类似物1-5（2-[（（18）F]氟乙氧基）-色氨酸（5-（18）FEHTP）的便捷的远程控制合成。 65分钟内的放射化学收率约为12-16％，无衰减校正，放射化学纯度超过98％，溶于盐水的5-（18）FEHTP在室温下超过6h稳定。 5-（18）FEHTP在小鼠中的生物分布以及肿瘤中5-（18）FEHTP的高摄取表明，它很可能是一种用于肿瘤成像的新型PET示踪剂。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2010年第2期|共6页
作者
Li R; Wu SC; Wang SC; Fu Z; Dang Y; Huo L;
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正文语种 eng
中图分类原子核物理学、高能物理学;放射医学;
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1. Synthesis and evaluation of l-5-(2-((18)F)fluoroethoxy)tryptophan as a new PET tracer. [J] . Li R, Wu SC, Wang SC, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2010,第2期

机译：新型PET示踪剂1-5（2-（（（18）F）氟乙氧基）色氨酸的合成与评价
2. Synthesis and biological evaluation of (18)F-labeled Fluoroethoxy tryptophan analogues as potential PET tumor imaging agents. [J] . Aristeidis Chiotellis, Adrienne Muller, Linjing Mu, Molecular pharmaceutics . 2014,第11期

机译：（18）F标记的氟乙氧基色氨酸类似物作为潜在的PET肿瘤显像剂的合成和生物学评估。
3. Synthesis and biological evaluation of (18)F-labeled Fluoroethoxy tryptophan analogues as potential PET tumor imaging agents. [J] . Aristeidis Chiotellis, Adrienne Muller, Linjing Mu, Molecular pharmaceutics . 2014,第11期

机译：（18）F标记的氟乙氧基色氨酸类似物作为潜在PET肿瘤成像试剂的合成与生物学评价。
4. RADIOSYNTHESIS AND IN VIVO EVALUATION IN MELANOMA-BEARING MICE OF O-(2- ~(18)FFLUOROETHYL)-L-TYROSINE AS A TUMOUR TRACER [C] . MINGWEI WANG, DUANZHI YIN, YONGXIAN WANG Trends in Radiopharmaceuticals(ISTR-2005) . 2007

机译：肿瘤示踪剂O-（2- 〜（18）F氟乙基）-酪氨酸的黑素瘤小鼠的放射合成及体内评价
5. Synthesis and Preliminary Evaluation of an F-18 Labeled Fluoropyridine Losartan Analog as a Novel PET Tracer for Imaging AT1 Receptors [D] . Arksey, Natasha 2012

机译：F-18标记的氟吡啶氯沙坦类似物作为新型PET示踪剂，用于AT1受体成像的合成和初步评估。
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7. Radiosynthesis and Radiotracer Properties of a 7-(2-[18F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET [O] . Maisonial-Besset, Aurélie, Funke, Uta, Deuther-Conrad, Winnie, 2012

机译：PET合成磷酸二酯酶10A的7-（2- [18F]氟乙氧基）-6-甲氧基吡咯烷基喹唑啉的放射合成和放射性示踪性质

Synthesis and evaluation of l-5-(2-((18)F)fluoroethoxy)tryptophan as a new PET tracer.

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