Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[ 18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([ 18F]-FMISO)

YokellD.L.; LeeceA.K.; LebedevA.; MiraghaieR.; BallC.E.; ZhangJ.; KolbH.; ElizarovA.; MahmoodU.

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Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[ 18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([ 18F]-FMISO)

机译：低氧示踪剂1H-1-（3- [18F]-氟-2-羟基-丙基）-2-硝基咪唑（[18F] -FMISO）的微流控单容器生产

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We report an automated synthesis of [ 18F]-FMISO utilizing a prototype microfluidic radiochemistry module. The instrument allows for production of the tracer with 58%±2% (11 runs) decay corrected yield. Total time of production, including synthesis and purification averages 60min. Use of the microfluidic platform results in a specific activity of 138.6GBq/μmol, which is higher than previously reported for conventional reactors.

机译：我们报告利用原型微流控放射化学模块自动合成[18F] -FMISO。该仪器允许以58％±2％（11次运行）的衰减校正产率生产示踪剂。包括合成和纯化在内的总生产时间平均为60分钟。使用微流体平台可产生138.6GBq /μmol的比活，比以前报道的常规反应器要高。

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |2012年第10期|共4页
作者
YokellD.L.; LeeceA.K.; LebedevA.; MiraghaieR.; BallC.E.; ZhangJ.; KolbH.; ElizarovA.; MahmoodU.;
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原文格式 PDF
正文语种 eng
中图分类原子核物理学、高能物理学;
关键词
FMISO; Microfluidic; PET;

机译：FMISO;微流控;PET;

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1. Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[ 18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([ 18F]-FMISO) [J] . YokellD.L., LeeceA.K., LebedevA., Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2012,第10期

机译：低氧示踪剂1H-1-（3- [18F]-氟-2-羟基-丙基）-2-硝基咪唑（[18F] -FMISO）的微流控单容器生产
2. Automated radiosynthesis of two 18F-labeled tracers containing 3-fluoro-2-hydroxypropyl moiety, [18F]FMISO and [18F]PM-PBB3, via [18F]epifluorohydrin [J] . Ohkubo Takayuki, Kurihara Yusuke, Ogawa Masanao, EJNMMI Radiopharmacy and Chemistry . 2021,第1期

机译：含有3-氟-2-羟丙基部分[18F] FMISO和[18F] PM-PBB3，通过[18F] EPIFLOOROLIN的自动覆盖合成含有3-氟-2-羟丙基部分，[18F] FMISO和[18F]的覆盖物
3. Noninvasive assessment of hypoxia with 3-[~18F]-fluoro-l-(2-nitro-l-imidazolyl)-2-propanol ([~18F]-FMISO): a PET study in two experimental models of human glioma [J] . Aurelien Corroyer-Dulmont, Elodie A. Peres, Edwige Petit, Biological chemistry . 2013,第4期

机译：用3- [〜18F]-氟-1-（2-硝基-咪唑基）-2-丙醇（[〜18F] -FMISO）进行缺氧性无创评估：在两个人类神经胶质瘤实验模型中的PET研究
4. Optimal Time of Single Static PET Scan to Determine Tumor Hypoxia with 18F-FMISO in Glioblastoma [C] . Redha-alla Abdo, Frédéric Lamare, Philippe Fernandez, IEEE Nuclear Science Symposium;Medical Imaging Conference . 2019

机译：用单次静态PET扫描确定胶质母细胞瘤中肿瘤18F-FMISO的最佳时间
5. Thinking inside the "box": Development and implementation of a novel automated radiosynthesizer for 18F-labeled positron emission tomography tracers. [D] . Lazari, Mark Saul. 2015

机译：在“盒子”内思考：开发和实施一种新型的自动放射性合成仪，用于18F标记的正电子发射断层显像示踪剂。
6. Microfluidic single vessel production of hypoxia tracer 1H-1-(3-18F-fluoro-2-hydroxy-propyl)-2-nitro-imidazole (18F-FMISO) [O] . Daniel L Yokell, Alicia K Leece, Artem Lebedev, -1

机译：缺氧示踪剂的微流体单血管生产1H-1-（3- 18F - 氟-2-羟丙基）-2-硝基 - 咪唑（18F -Fmiso）
7. Comparison of 18F-FMISO, 18F-FAZA and 18F-HX4 for PET imaging of hypoxia – a simulation study [O] . Linda J. Wack, David Mönnich, Wouter van Elmpt, 2015

机译：18F -fmiso，18F -Faza和18F -HX4对缺氧的宠物成像的比较 - 模拟研究

Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[ 18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([ 18F]-FMISO)

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