Reactivity of p-[↑(18)F]Fluorophenacyl Bromide for Radiolabeling of Proteins and Peptides

JOANNA B. DOWNER; TIMOTHY J. McCARTHY; W. BARRY EDWARDS

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Reactivity of p-[↑(18)F]Fluorophenacyl Bromide for Radiolabeling of Proteins and Peptides

机译：p- [↑（18）F]氟苯甲酰溴对蛋白质和肽的放射性标记反应

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Radiolabeling of the somatostatin analog octreotide was attempted with p-[↑(18)F]fluorophenacyl bromide ([↑(18)F]FPB). Following these unsuccessful trials, the reactivity of FPB was studied using benzyl mercaptan. phenyl acetic acid, benzyl alcohol, and benzyl amine as model compounds for amino acid functional groups. Structure and purity of products, relative reactivity of FPB in competition reactions, and radiolabeling experiments are described. In addition, improvement in labeling efficiency of HSA using [↑(18)F]FPB was achieved by pretreatment with 2-iminothiolane. #1997 Elsevier Science Ltd

机译：尝试用对-[↑（18）F]氟苯甲酰溴（[↑（18）F] FPB）放射性标记生长抑素类似物奥曲肽。在这些失败的试验之后，使用苄基硫醇研究了FPB的反应性。苯乙酸，苯甲醇和苄胺作为氨基酸官能团的模型化合物。描述了产物的结构和纯度，FPB在竞争反应中的相对反应性以及放射性标记实验。另外，通过用2-亚氨基硫烷预处理可以提高使用[↑（18）F] FPB的HSA标记效率。＃1997爱思唯尔科学有限公司

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《Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine》 |1997年第7期|共10页
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JOANNA B. DOWNER; TIMOTHY J. McCARTHY; W. BARRY EDWARDS;
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中图分类原子核物理学、高能物理学;放射医学;
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1. Reactivity of p-[↑(18)F]Fluorophenacyl Bromide for Radiolabeling of Proteins and Peptides [J] . JOANNA B. DOWNER, TIMOTHY J. McCARTHY, W. BARRY EDWARDS Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 1997,第7期

机译：p- [↑（18）F]氟苯甲酰溴对蛋白质和肽的放射性标记反应
2. Automated radiosynthesis of N-succinimidyl 3-(di-tert-butyl[~(18)F] fluorosilyl)benzoate ([~(18)F]SiFB) for peptides and proteins radiolabeling for positron emission tomography [J] . R. Koudih, A. Kostikov, M. Kovacevic, Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine . 2014,第Null期

机译：N-琥珀酰亚胺基3-（[[（（18）F]氟甲硅烷基）苯甲酸叔丁酯（[〜（18）F] SiFB）的自动放射合成，用于肽和蛋白质的放射标记，用于正电子发射断层扫描
3. Systematic comparison of two novel, thiol-reactive prosthetic groups for 18F labeling of peptides and proteins with the acylation agent succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) [J] . Frank Wuest, Lena Köhler, Mathias Berndt, Amino Acids . 2009,第2期

机译：用酰化剂琥珀酰亚胺基-4-[ 18 F]氟苯甲酸酯（[ F标记的肽和蛋白质的两个新型巯基反应性修复基团的系统比较> 18 F] SFB）
4. Reactive Electrospray-Assisted Laser Desorption Ionization (Reactive ELDI) for Characterization of Peptides and Proteins [C] . Ivory X. Peng, Rachel R. Ogorzalek Loo, Jentaie Shiea, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：反应电喷雾辅助激光解吸电离（反应性ELDI），用于表征肽和蛋白质
5. Evaluation of Phosphatidylserine-Binding Peptides Radiolabeled with Fluorine 18 for in vivo Imaging of Apoptosis [D] . Kapty, Janice Sarah 2012

机译：氟18放射性标记的磷脂酰丝氨酸结合肽在体内凋亡成像中的评估
6. Automated Radiochemical Synthesis of 18FFBEM: a Thiol Reactive Synthon for Radiofluorination of Peptides and Proteins [O] . Dale O. Kiesewetter, Orit Jacobson, Lixin Lang, -1

机译：18F FBEM的自动放射化学合成：用于肽和蛋白质的酰基氟化的硫醇反应合成酮
7. Automated radiochemical synthesis of [18F]FBEM: A thiol reactive synthon for radiofluorination of peptides and proteins [O] . Dale O. Kiesewetter, Orit Jacobson, Lixin Lang, 2015

机译：自动放射化学合成[18F] FBEm：一种硫醇反应性合成子，用于肽和蛋白质的放射性氟化

Reactivity of p-[↑(18)F]Fluorophenacyl Bromide for Radiolabeling of Proteins and Peptides

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