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首页> 外文期刊>Applied radiation and isotopes: including data, instrumentation and methods for use in agriculture, industry and medicine >Evaluation of patients with hepatocellular carcinomas using ((11)C)acetate and ((18)F)FDG PET/CT: A preliminary study.
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Evaluation of patients with hepatocellular carcinomas using ((11)C)acetate and ((18)F)FDG PET/CT: A preliminary study.

机译：使用（（11）C）乙酸酯和（（18）F）FDG PET / CT对肝细胞癌患者的评估：一项初步研究。

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摘要

It is well known that [(18)F]FDG PET has a low sensitivity in the detection of hepatocellular carcinoma (HCC). We prospectively compared [(11)C]acetate PET/CT results with those of [(18)F]FDG PET/CT in patients with HCCs. Thirteen patients (M:F=11:2, mean age of 51+/-12) with suspicious or confirmed HCCs underwent [(11)C]acetate PET/CT with or without [(18)F]FDG PET/CT (both [(11)C]acetate and [(18)F]FDG PET/CT were performed in 10 patients). HCC was confirmed by histopathology or clinical criteria in 12 patients and one benign liver lesion. Both PET/CT images were interpreted by two experienced nuclear physicians, supported by standardized uptake value (SUV). A total of 12 patients were confirmed to have initial or recurrent HCCs. [(18)F]FDG PET/CT showed markedly increased uptake in only two patients, moderately increased uptake in another two and negative in six. [(11)C]acetate PET/CT demonstrated markedly increased uptake in seven patients, moderately increased uptake in three and negative in only two. One HCC metastatic lesion was detected only by [(11)C]acetate PET/CT. For detection of HCC, [(11)C]acetate PET/CT showed a high sensitivity of 83%, whereas [(18)F]FDG PET/CT only of 40%. The study results demonstrated that [(18)F]FDG PET/CT has a limitation in detection of HCC and [(11)C]acetate PET/CT has a complementary role to [(18)F]FDG PET/CT. When primary HCC showed low [(18)F]FDG uptake, it was [(11)C]acetate-avid, and vice versa. It may be useful to combine both [(18)F]FDG and [(11)C]acetate PET/CT for detection of HCCs.
机译：众所周知，[（18）F] FDG PET在肝细胞癌（HCC）的检测中灵敏度较低。我们对肝癌患者的[（11）C]醋酸酯PET / CT结果与[[18] F] FDG PET / CT结果进行了比较。 13例可疑或确诊的HCC患者（M：F = 11：2，平均年龄为51 +/- 12），在[（11）C]醋酸PET / CT或不加[[18] F] FDG PET / CT的情况下（ [（11）C]乙酸盐和[（18）F] FDG PET / CT均在10例患者中进行。通过组织病理学或临床标准在12例患者和1例肝良性病变中证实了HCC。两个PET / CT图像均由两名经验丰富的核医学医师进行解释，并得到标准化摄取值（SUV）的支持。总共有12名患者被确认患有初始或复发性HCC。 [（18）F] FDG PET / CT仅显示两名患者的摄取显着增加，另外两名患者中度摄取增加，六名患者中阴性。 [（11）C]醋酸盐PET / CT证明7名患者的摄取显着增加，三名患者的摄取适度增加，只有2名患者为阴性。仅通过[（11）C]乙酸PET / CT检测到一种HCC转移性病变。对于HCC的检测，[（11）C]乙酸酯PET / CT显示出83％的高灵敏度，而[（18）F] FDG PET / CT仅显示40％。研究结果表明，[（18）F] FDG PET / CT在检测HCC方面存在局限性，[[11] C]乙酸酯PET / CT与[（18）F] FDG PET / CT具有互补作用。当原发性肝癌显示出低的[（18）F] FDG摄取时，它是[（11）C]乙酸酯-avid，反之亦然。结合使用[（18）F] FDG和[[11] C]乙酸酯PET / CT来检测HCC是有用的。

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