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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.
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The biological relevance of FHL2 in tumour cells and its role as a putative cancer target.

机译：FHL2在肿瘤细胞中的生物学相关性及其作为假定的癌症靶标的作用。

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摘要

The LIM-only protein FHL2 (four-and-a-half LIM-domain protein 2) belongs to the FHL protein family of transcriptional cofactors present in various cell lines. FHL2 interacts with a variety of transcription factors known to be involved in tumour development. Furthermore, FHL2 expression is often deregulated in cancer including overexpression and down-regulation in various types of tumours. The function of FHL2 in cancer is particularly intriguing, since it may act as an oncoprotein or as a tumour suppressor in a tissue-dependent fashion. This dual nature of FHL2 is also reflected by the finding that it can function as repressor or activator of transcriptional activity depending on the cell-type. The ability of FHL2 to exert functional diversity lies within its structural composition as a LIM-only protein. LIM-domains are enzymatically inactive protein-to-protein interaction domains, which determine the function of LIM-only proteins as adaptor molecules or scaffolding proteins. By selectively using different LIM-domains for protein-to-protein interactions, FHL2 is capable to interact with a broad spectrum of functionally unrelated proteins, thereby triggering different signalling pathways. In this review, the current knowledge of FHL2 expression in different cancers was summarized and the interaction of FHL2 with transcription factors and other proteins involved in cancer development was examined. Since transcription factors control all fundamental developmental and homeostatic processes, transcriptional cofactors like FHL2 are likely to contribute to human carcinogenesis and are of clinical importance in various forms of cancer.
机译：仅LIM的蛋白FHL2（四个半LIM域蛋白2）属于各种细胞系中转录辅助因子的FHL蛋白家族。 FHL2与已知参与肿瘤发展的多种转录因子相互作用。此外，在各种类型的肿瘤中，FHL2表达通常在癌症中失调，包括过度表达和下调。 FHL2在癌症中的功能特别引人入胜，因为它可以以依赖组织的方式充当癌蛋白或肿瘤抑制物。 FHL2的这种双重性质还反映在以下发现中：它可以根据细胞类型充当转录活性的阻遏物或激活物。 FHL2发挥功能多样性的能力在于其结构组成（仅LIM）。 LIM结构域是无酶活性的蛋白间相互作用结构域，它决定了仅LIM的蛋白作为衔接分子或支架蛋白的功能。通过选择性地使用不同的LIM域进行蛋白质间相互作用，FHL2能够与功能上不相关的多种蛋白质相互作用，从而触发不同的信号传导途径。在这篇综述中，总结了FHL2在不同癌症中表达的当前知识，并研究了FHL2与转录因子和参与癌症发展的其他蛋白质的相互作用。由于转录因子控制所有基本的发育和体内平衡过程，因此转录辅助因子（如FHL2）可能会促进人类致癌作用，并且在各种形式的癌症中具有重要的临床意义。

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