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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Histone deacetylase inhibitors, but not vincristine, cooperate with radiotherapy to induce cell death in medulloblastoma.
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Histone deacetylase inhibitors, but not vincristine, cooperate with radiotherapy to induce cell death in medulloblastoma.

机译：组蛋白脱乙酰基酶抑制剂（而非长春新碱）与放疗配合使用可诱导髓母细胞瘤中的细胞死亡。

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BACKGROUND: Though ionising radiation (IR) is an efficient means of postoperative treatment for children with medulloblastoma, the disease is incurable in about a third of them. Thus, multimodality regimens have been introduced, typically combining IR with vincristine. MATERIALS AND METHODS: The combination of IR and vincristine was compared to the combination of IR and histone deacetylase inhibitors (HDIs) for their anticancer activity against medulloblastoma cells in vitro. Cytotoxic activities were assessed by measuring propidium iodide uptake and by cell cycle analysis. RESULTS: HDIs augmented the cytotoxic effect of IR, while the combination of vincristine and IR was significantly less cytotoxic than vincristine alone. Cell cycle analyses revealed that vincristine did not interfere with IR-induced G2/M arrest, whereas HDIs abolished the latter. CONCLUSION: These in vitro findings indicate a favourable interaction of IR and HDIs, but an unfavourable one of IR and vincristine, in medulloblastoma, and provide a rationale for comparing the combination of IR with either vincristine or HDIs in vivo.
机译：背景：尽管电离辐射（IR）是髓母细胞瘤儿童术后治疗的有效手段，但这种疾病在大约三分之一的儿童中是无法治愈的。因此，已经引入了多模式疗法，通常将IR与长春新碱相结合。材料与方法：将IR和长春新碱的组合与IR和组蛋白脱乙酰基酶抑制剂（HDI）的组合在体外对髓母细胞瘤细胞的抗癌活性进行了比较。通过测量碘化​​丙锭的摄取并通过细胞周期分析来评估细胞毒性活性。结果：HDIs增强了IR的细胞毒性作用，而长春新碱和IR的组合的细胞毒性明显低于单独的长春新碱。细胞周期分析显示长春新碱不会干扰IR诱导的G2 / M阻滞，而HDI则消除了后者。结论：这些体外研究结果表明，在髓母细胞瘤中，IR和HDI之间存在良好的相互作用，但IR和长春新碱之间却存在不利的相互作用，为比较IR与长春新碱或HDI的体内结合提供了理论依据。

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