Salen-manganese complexes: sophisticated tools for the analysis of intercellular ROS signaling pathways.

Ophoven SJ; Bauer G

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Salen-manganese complexes: sophisticated tools for the analysis of intercellular ROS signaling pathways.

机译：Salen-锰配合物：用于分析细胞间ROS信号通路的精密工具。

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Salen-manganese complexes, such as EUK-8 and EUK-134 are known as catalase mimetics with superoxide dismutase (SOD) and peroxidase mimetic activity. Here we show that the concentration-dependent use of salen-manganese complexes within the appropriate time window and with parallel control of signaling parameters allows complex interactions during intercellular induction of apoptosis to be studied. At very low concentrations, salen-manganese complexes can abrogate consumption reactions between HOCl and hydrogen peroxide, as well as NO and hydrogen peroxide, and thus the major signaling pathways are enhanced. At higher concentrations of the compounds, all major signaling pathways are inhibited, thereby the catalase mimetic activity of the compounds affects both hydrogen peroxide and peroxynitrite. The ratio between available hydrogen peroxide and salen-manganese complexes defines whether reactive oxygen species (ROS) effects are inhibited or apoptosis is induced by the compounds. The SOD mimetic activity of salen-manganese complexes seems to be insufficient to interfere with intercellular ROS signaling.

机译：Salen-锰络合物（例如EUK-8和EUK-134）被称为具有超氧化物歧化酶（SOD）和过氧化物酶模拟活性的过氧化氢酶模拟物。在这里，我们显示了在适当的时间窗口内并以平行控制的信号传导参数对salen-锰配合物的浓度依赖性使用，可以研究细胞间诱导凋亡过程中的复杂相互作用。在非常低的浓度下，salen-锰络合物可以消除HOCl和过氧化氢之间以及NO和过氧化氢之间的消耗反应，因此增强了主要的信号传导途径。在较高浓度的化合物下，所有主要的信号传导途径均被抑制，从而化合物的过氧化氢酶模拟活性影响过氧化氢和过氧亚硝酸盐。可用的过氧化氢和Salen-锰配合物之间的比例定义了化合物是否抑制了活性氧（ROS）的作用或诱导了细胞凋亡。 Salen-锰配合物的SOD模拟活性似乎不足以干扰细胞间ROS信号传导。

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《Anticancer Research: International Journal of Cancer Research and Treatment》 |2010年第10期|共13页
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Ophoven SJ; Bauer G;
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中图分类肿瘤学;
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Salen-manganese complexes: sophisticated tools for the analysis of intercellular ROS signaling pathways.

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