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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan.
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Association of cyclooxygenase 2 polymorphic genotypes with prostate cancer in taiwan.

机译：台湾的环氧合酶2多态性基因型与前列腺癌的关系。

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摘要

The aim of this study was to evaluate the association of polymorphic genotypes in the cyclooxygenase 2 gene (COX2), which is reported to be overexpressed in prostate tumors, with Taiwan prostate cancer patients. MATERIALS AND METHODS: Six polymorphic variants of COX2 were analyzed for their association with prostate cancer susceptibility. A total of 218 patients with prostate cancer and 436 healthy controls in central Taiwan were enrolled in this investigation. P-values and odds ratios with 95% confidence intervals were used to assess the strength of the association. RESULTS: Among the six polymorphic sites examined, only the Cox-2 promoter G-765C (rs14133) genotypes were distributed differently between the prostate cancer and control groups. The COX2 -765GG genotype was associated with higher prostate cancer risk than -765GC. CONCLUSION: These findings provide evidence that the G allele of COX2 promoter G-765C may be associated with the development of prostate cancer and may be a useful marker for early detection of prostate cancer.
机译：这项研究的目的是评估环氧合酶2基因（COX2）中的多态性基因型与台湾前列腺癌患者的相关性，据报道该基因在前列腺肿瘤中过表达。材料与方法：分析了六个COX2多态性变异体与前列腺癌易感性的关系。台湾中部地区共有218例前列腺癌患者和436名健康对照者参加。具有95％置信区间的P值和比值比用于评估关联的强度。结果：在检查的六个多态性位点中，只有Cox-2启动子G-765C（rs14133）基因型在前列腺癌和对照组之间的分布不同。与-765GC相比，COX2 -765GG基因型与更高的前列腺癌风险相关。结论：这些发现提供了证据，表明COX2启动子G-765C的G等位基因可能与前列腺癌的发展有关，并且可能是早期检测前列腺癌的有用标志物。

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