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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Expression of metastasis associated proteins, CD44v6 and NM23-H1, in pediatric acute lymphoblastic leukemia.
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Expression of metastasis associated proteins, CD44v6 and NM23-H1, in pediatric acute lymphoblastic leukemia.

机译：转移相关蛋白CD44v6和NM23-H1在小儿急性淋巴细胞白血病中的表达。

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摘要

Two metastasis-associated proteins, CD44v6 and NM23-H1, are expressed by normal lymphoid cells, the former serving as activation marker and the latter as a constitutive protein. CD44v6 is considered as a marker of poor prognosis of various hematological cancers but its expression was not demonstrated in childhood acute lymphoblastic leukaemia (ALL). On the other hand, NM23-H1 is considered as a differentiation inhibitory factor in various hematological cancers and as a marker of poor prognosis. Therefore we analyzed the expression of CD44v6 and NM23-H1 in the bone marrow of sixteen pediatric ALL patients using immunocytochemistry. For the first time, we have demonstrated the expression of CD44v6 protein epitopes on leukemic cells in a proportion of ALL cases (6 out of 16), primarily in the medium/high risk group (except one case), suggesting a possible association to an unfavourable outcome. On the other hand, NM23-H1 protein expression was maintained in leukaemic cells in 50% of both low and medium/high risk ALL cases. The majority of the pediatric ALL cases expressed only one of the metastasis-associated proteins (10 out of 16). This feature is similar to the observations made in several adult solid cancers. The potential of CD44v6 expression in leukaemic cells as prognosticator in pediatric ALL should be evaluated in a larger clinical trial.
机译：正常淋巴样细胞表达两种与转移相关的蛋白CD44v6和NM23-H1，前者充当激活标记，后者充当组成性蛋白。 CD44v6被认为是各种血液学癌症预后不良的标志，但在儿童急性淋巴细胞白血病（ALL）中未证明其表达。另一方面，NM23-H1被认为是各种血液癌症中的分化抑制因子，并且是预后不良的标志。因此，我们使用免疫细胞化学分析了CD44v6和NM23-H1在16例小儿ALL患者骨髓中的表达。首次，我们证明了一部分ALL病例（16例中有6例）主要在中/高危组（除一例外）中白血病细胞上CD44v6蛋白表位的表达，提示可能与白血病相关。不利的结果。另一方面，在低危和中/高危ALL病例中，白血病细胞中NM23-H1蛋白表达得以维持。大多数儿科ALL病例仅表达一种与转移相关的蛋白（16个中有10个）。此功能类似于在几种成人实体癌中所做的观察。应在更大的临床试验中评估白血病细胞中CD44v6表达作为小儿ALL预后的潜力。

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