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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer.
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Immunochemical staining of MT2-MMP correlates positively to angiogenesis of human esophageal cancer.

机译：MT2-MMP的免疫化学染色与人食道癌的血管生成呈正相关。

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摘要

Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas none or very weak MT2-MMP staining occurred in normal esophageal tissues. In addition, MT2-MMP immunochemical intensities were significantly correlated to tumor size, but not to patient's gender, age, invasion depth, lymph node metastasis and distant metastasis. Moreover, MT2-MMP levels could not be applied for predicting patients' survival rate although the H-score cut-off value showed the overall survival rate of patients with low MT2-MMP protein level to be better than those with high MT2-MMP protein level.
机译：基质金属蛋白酶（MMPs）在细胞外基质降解和基底膜破坏的病理过程中起重要作用，导致肿瘤的侵袭和转移。在本研究中，我们调查了收集自103例患者的食道癌组织中2型膜MMP（MT2-MMP）的表达模式，并探讨了MT2-MMP表达模式与患者的临床病理特征，肿瘤内血管生成和术后预后的相关性。 MT2-MMP的免疫化学染色强度与食管癌组织的肿瘤内血管生成显着正相关。在总肿瘤切片的85.4％中发现阳性的MT2-MMP免疫反应，而在正常的食管组织中没有或仅有非常弱的MT2-MMP染色。此外，MT2-MMP免疫化学强度与肿瘤大小显着相关，而与患者的性别，年龄，浸润深度，淋巴结转移和远处转移无关。此外，尽管H值截止值表明MT2-MMP蛋白水平低的患者的总体生存率要好于MT2-MMP蛋白水平高的患者，但MT2-MMP水平不能用于预测患者的生存率水平。

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