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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma.
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Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma.

机译：在晚期胃癌中经常检测到TFPI2基因的甲基化。

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BACKGROUND: Recently, Glockner et al. identified the methylation of TFPI2 as a frequent event in human colorectal cancer using a gene expression array-based strategy. MATERIALS AND METHODS: Methylation status of the TFPI2 gene was examined in primary carcinomas and the corresponding normal tissues derived from 38 patients with gastric cancer using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. RESULTS: Aberrant methylation of the TFPI2 gene was detected in 7 out of 38 (18%) primary gastric carcinomas, suggesting that the methylation of TFPI2 is frequently observed in gastric carcinomas. The clinicopathological data were correlated with the methylation results. A significant difference was observed in maximal tumour size (p=0.0084), extent of tumour (p=0.0068), and TNM stage (p=0.0392). CONCLUSION: TFPI2 is frequently methylated in advanced gastric carcinomas.
机译：背景：最近，Glockner等人。使用基于基因表达阵列的策略，发现TFPI2的甲基化是人类大肠癌的常见事件。材料与方法：使用定量甲基化特异性PCR（qMSP）检测了38例胃癌患者的原发癌和相应的正常组织中TFPI2基因的甲基化状态，并评估了甲基化状态与临床病理结果之间的相关性。结果：在38例原发性胃癌中，有7例（18％）检测到TFPI2基因异常甲基化，这表明在胃癌中经常观察到TFPI2甲基化。临床病理数据与甲基化结果相关。在最大肿瘤大小（p = 0.0084），肿瘤程度（p = 0.0068）和TNM分期（p = 0.0392）中观察到显着差异。结论：TFPI2在晚期胃癌中经常被甲基化。

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