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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Gastric carcinomas of intestinal type concur with distant changes in the gastric mucosa. A multicenter study in the Atlantic basin.
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Gastric carcinomas of intestinal type concur with distant changes in the gastric mucosa. A multicenter study in the Atlantic basin.

机译：肠型胃癌伴有胃粘膜的远处改变。大西洋盆地的多中心研究。

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摘要

Population studies in the Pacific Basin showed that gastric carcinomas of intestinal type often concur with distant mucosal changes (DMCs). In the present work, the presence of DMCs was investigated in populations dwelling in the Atlantic Basin. A total of 1737 gastrectomy specimens were reviewed: 627 in New York, 435 in Reykjavik, 198 in Buenos Aires, 186 in Florence, 174 in London and the remaining 117 in Stockholm. A total of 17,282 sections were carefully scrutinized. The following DMCs were investigated: intramucosal glandular cysts, gastric cells with ciliated metaplasia, with large or small mucus negative vacuoles, and extensive intestinal metaplasia (IM). The highest frequencies of DMCs were found in Florence for specimens with intestinal type carcinoma: 41.3% had intramucosal cysts, 22.4% had cells with ciliated metaplasia, 12.9% cells with large vacuoles, and 50.9% had high IM. The highest frequency of gastric cells with small vacuoles was recorded in New York (9.1%), also in specimens with intestinal type carcinoma. Significantly lower DMCs percentages were found in specimens with carcinomas of diffuse type, and miscellaneous gastric diseases. The occurrence of DMCs was not influenced to a significant degree by the number of sections available per gastrectomy. Since environmental factors trigger the evolution of intestinal type carcinomas and as DMCs also occurred in specimens without carcinoma-although at a significantly lower rate--it is conceivable that DMCs are also evoked by environmental factors (before a gastric carcinoma ensues). DMCs were found in specimens having intestinal carcinomas either in the cardia, the corpus or the antrum. Thus, DMCs seem to provide the adequate "soil" for the development of gastric carcinomas of intestinal type, independently of the future localization of that tumor in the stomach.
机译：在太平洋盆地进行的人口研究显示，肠型胃癌通常同时伴有远处的粘膜变化（DMC）。在目前的工作中，对居住在大西洋盆地的人口中DMC的存在进行了调查。共审查了1737例胃切除术标本：纽约627例，雷克雅未克435例，布宜诺斯艾利斯198例，佛罗伦萨186例，伦敦174例，斯德哥尔摩117例。总共仔细检查了17,282个切片。研究了以下DMC：粘膜内腺囊肿，具有纤毛化生，具有大或小的粘液阴性液泡的胃细胞以及广泛的肠化生（IM）。在佛罗伦萨发现的肠型癌标本中DMC的频率最高：粘膜内囊肿占41.3％，纤毛化生细胞占22.4％，液泡大的细胞占12.9％，IM高。50.9％。在纽约，有小液泡的胃细胞出现频率最高（9.1％），也有肠型癌标本。在患有弥漫型癌和其他胃病的标本中发现DMCs的百分比明显降低。 DMCs的发生在很大程度上不受每个胃切除术可用的切片数量的影响。由于环境因素触发了肠道型癌的发展，并且在无癌的标本中也发生了DMC，尽管发生率显着降低（可以想象，DMC也被环境因素诱发（在胃癌发生之前））。在MC门，the体或胃窦均患有肠癌的标本中发现了DMC。因此，DMCs似乎为肠型胃癌的发展提供了足够的“土壤”，而与该肿瘤在胃中的未来定位无关。

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